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Baseline Urinary Tract Imaging in Infants Enrolled in the UMPIRE Protocol for Children with Spina Bifida.

Publication ,  Journal Article
Tanaka, ST; Paramsothy, P; Thibadeau, J; Wiener, JS; Joseph, DB; Cheng, EY; Tu, D; Austin, C; Koh, CJ; Wallis, MC; Walker, WO; Smith, KA ...
Published in: J Urol
June 2019

PURPOSE: The lifetime risk of renal damage in children with spina bifida is high but only limited baseline imaging data are available for this population. We evaluated a large prospective cohort of infants with spina bifida to define their baseline imaging characteristics. MATERIALS AND METHODS: The UMPIRE Protocol for Young Children with Spina Bifida is an iterative quality improvement protocol that follows a cohort of newborns at 9 United States centers. Using descriptive statistics, we report the initial baseline imaging characteristics, specifically regarding renal bladder ultrasound, cystogram and dimercaptosuccinic acid nuclear medicine scan. RESULTS: Data on 193 infants from 2015 to 2018 were analyzed. Renal-bladder ultrasound was normal in 55.9% of infants, while 40.4% had Society for Fetal Urology grade 1 to 2 hydronephrosis in at least 1 kidney, 3.7% had grade 3 to 4 hydronephrosis in either kidney and 21.8% had grade 1 or higher bilateral hydronephrosis. There was no vesicoureteral reflux in 84.6% of infants. A third of enrolled infants underwent dimercaptosuccinic acid nuclear medicine renal scan, of whom 92.4% had no renal defects and 93.9% had a difference in differential function of less than 15%. CONCLUSIONS: The majority of infants born with spina bifida have normal baseline imaging characteristics and normal urinary tract anatomy at birth. This proactive protocol offers careful scheduled surveillance of the urinary tract with the goal of lifelong maintenance of normal renal function and healthy genitourinary development.

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Published In

J Urol

DOI

EISSN

1527-3792

Publication Date

June 2019

Volume

201

Issue

6

Start / End Page

1193 / 1198

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urologic Diseases
  • Urinary Tract
  • Spinal Dysraphism
  • Prospective Studies
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Female
 

Citation

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Chicago
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Tanaka, S. T., Paramsothy, P., Thibadeau, J., Wiener, J. S., Joseph, D. B., Cheng, E. Y., … Baum, M. A. (2019). Baseline Urinary Tract Imaging in Infants Enrolled in the UMPIRE Protocol for Children with Spina Bifida. J Urol, 201(6), 1193–1198. https://doi.org/10.1097/JU.0000000000000141
Tanaka, Stacy T., Pangaja Paramsothy, Judy Thibadeau, John S. Wiener, David B. Joseph, Earl Y. Cheng, Duong Tu, et al. “Baseline Urinary Tract Imaging in Infants Enrolled in the UMPIRE Protocol for Children with Spina Bifida.J Urol 201, no. 6 (June 2019): 1193–98. https://doi.org/10.1097/JU.0000000000000141.
Tanaka ST, Paramsothy P, Thibadeau J, Wiener JS, Joseph DB, Cheng EY, et al. Baseline Urinary Tract Imaging in Infants Enrolled in the UMPIRE Protocol for Children with Spina Bifida. J Urol. 2019 Jun;201(6):1193–8.
Tanaka, Stacy T., et al. “Baseline Urinary Tract Imaging in Infants Enrolled in the UMPIRE Protocol for Children with Spina Bifida.J Urol, vol. 201, no. 6, June 2019, pp. 1193–98. Pubmed, doi:10.1097/JU.0000000000000141.
Tanaka ST, Paramsothy P, Thibadeau J, Wiener JS, Joseph DB, Cheng EY, Tu D, Austin C, Koh CJ, Wallis MC, Walker WO, Smith KA, Routh JC, Baum MA. Baseline Urinary Tract Imaging in Infants Enrolled in the UMPIRE Protocol for Children with Spina Bifida. J Urol. 2019 Jun;201(6):1193–1198.
Journal cover image

Published In

J Urol

DOI

EISSN

1527-3792

Publication Date

June 2019

Volume

201

Issue

6

Start / End Page

1193 / 1198

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urologic Diseases
  • Urinary Tract
  • Spinal Dysraphism
  • Prospective Studies
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Female