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Lymphocyte telomere length predicts clinical outcomes of HPV-positive oropharyngeal cancer patients after definitive radiotherapy.

Publication ,  Journal Article
Luo, X; Sturgis, EM; Yang, Z; Sun, Y; Wei, P; Liu, Z; Wei, Q; Li, G
Published in: Carcinogenesis
July 6, 2019

Because lymphocyte telomere length (LTL) plays critical roles in the maintenance of genomic stability and integrity, LTL thus may influence the etiology and prognosis of squamous cell carcinoma of the oropharynx (SCCOP). However, given the association between LTL and risk of human papillomavirus (HPV)-associated SCCOP and between LTL and tumor HPV status of SCCOP, we hypothesized that LTL is associated with SCCOP prognosis, particularly in HPV-positive patients after definitive radiotherapy. LTL and tumor HPV type 16 (HPV16) status were determined in 564 incident SCCOP patients before radiotherapy or chemoradiation. Both univariate and multivariable Cox regression analyses were performed to estimate the association between LTL and prognosis. Eighty-five percent patients had HPV16-positive tumors. Patients with shorter telomeres had significantly better overall, disease-specific and disease-free survival than did those with longer telomeres (log-rank P < 0.001). Moreover, patients with shorter telomeres had significantly lower risk of death overall [hazard ratio (HR) = 0.2; 95% confidence interval (CI) = 0.1-0.4], death due to SCCOP (HR = 0.2; 95% CI = 0.1-0.4) and SCCOP recurrence (HR = 0.3; 95% CI = 0.2-0.5) after adjusting for other important prognostic confounders. Finally, we found more pronounced effects of LTL on survival in HPV16-positive SCCOP patients after stratified analysis according to tumor HPV status. These findings indicate that LTL plays a significant role in the survival of patients with SCCOP, especially HPV16-positive patients who undergo definitive radiotherapy. Therefore, pretreatment LTL may be an independent prognostic biomarker for HPV16-positive SCCOP. Prospective studies with larger sample sizes are needed to confirm these findings.

Duke Scholars

Published In

Carcinogenesis

DOI

EISSN

1460-2180

Publication Date

July 6, 2019

Volume

40

Issue

6

Start / End Page

735 / 741

Location

England

Related Subject Headings

  • Tumor Virus Infections
  • Treatment Outcome
  • Telomere
  • Squamous Cell Carcinoma of Head and Neck
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lymphocytes
  • Humans
 

Citation

APA
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ICMJE
MLA
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Luo, X., Sturgis, E. M., Yang, Z., Sun, Y., Wei, P., Liu, Z., … Li, G. (2019). Lymphocyte telomere length predicts clinical outcomes of HPV-positive oropharyngeal cancer patients after definitive radiotherapy. Carcinogenesis, 40(6), 735–741. https://doi.org/10.1093/carcin/bgz019
Luo, Xiaoning, Erich M. Sturgis, Zheng Yang, Yan Sun, Peng Wei, Zhensheng Liu, Qingyi Wei, and Guojun Li. “Lymphocyte telomere length predicts clinical outcomes of HPV-positive oropharyngeal cancer patients after definitive radiotherapy.Carcinogenesis 40, no. 6 (July 6, 2019): 735–41. https://doi.org/10.1093/carcin/bgz019.
Luo X, Sturgis EM, Yang Z, Sun Y, Wei P, Liu Z, et al. Lymphocyte telomere length predicts clinical outcomes of HPV-positive oropharyngeal cancer patients after definitive radiotherapy. Carcinogenesis. 2019 Jul 6;40(6):735–41.
Luo, Xiaoning, et al. “Lymphocyte telomere length predicts clinical outcomes of HPV-positive oropharyngeal cancer patients after definitive radiotherapy.Carcinogenesis, vol. 40, no. 6, July 2019, pp. 735–41. Pubmed, doi:10.1093/carcin/bgz019.
Luo X, Sturgis EM, Yang Z, Sun Y, Wei P, Liu Z, Wei Q, Li G. Lymphocyte telomere length predicts clinical outcomes of HPV-positive oropharyngeal cancer patients after definitive radiotherapy. Carcinogenesis. 2019 Jul 6;40(6):735–741.
Journal cover image

Published In

Carcinogenesis

DOI

EISSN

1460-2180

Publication Date

July 6, 2019

Volume

40

Issue

6

Start / End Page

735 / 741

Location

England

Related Subject Headings

  • Tumor Virus Infections
  • Treatment Outcome
  • Telomere
  • Squamous Cell Carcinoma of Head and Neck
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lymphocytes
  • Humans