Effects of arotinolol hydrochloride on circadian rhythm of blood pressure in patients with essential hypertention
The introduction of 24-hour monitoring of blood pressure using ambulatory blood pressure monitoring (ABPM) has revealed the presence of white coat hypertension, a sudden blood pressure rise in early morning (morning surge), and dipper and non-dipper type of blood pressure during the night, which were not found by conventional occasional pressure measurement. Moreover, it has been shown that 24-hour blood pressure patterns are closely associated with the occurrence and development of cardiovascular disease and organ dysfunction. In the present study, we examined the effects of arotinolol hydrochloride, an α-β adrenoreceptor blocking agent, on the circadian rhythm of blood pressure in 21 patients (mean age 63.6 years) with essential hypertension using ABPM. Satisfactory anti-hypertensive effect was obtained on administration of the test drug throughout 24 hour without any effect on the pattern of circadian rhythm. In the study in which dipper and non-dipper type. From these results, a more satisfactory anti-hypertensive effect was confirmed in the non-dipper type. From these results, the test drug was found to induce a stable anti-hypertensive effect without influencing the circadian rhythm of blood pressure.
