Identification of a protective proteomic signature and a potential therapeutic target in diabetic nephropathy.
Publication
, Journal Article
Chun, N; Wyatt, CM; He, JC
Published in: Kidney Int
October 2017
In a recent paper in Nature Medicine, Qi et al. set out to identify protective pathways in patients with longstanding diabetes who do not develop diabetic nephropathy. Unbiased proteomic analysis of kidney tissue identified a unique protein signature in unaffected individuals. Studies in vitro and in murine models identified the highly upregulated glycolytic enzyme pyruvate kinase M2 as a potential therapeutic target to prevent or treat diabetic nephropathy.
Duke Scholars
Published In
Kidney Int
DOI
EISSN
1523-1755
Publication Date
October 2017
Volume
92
Issue
4
Start / End Page
780 / 781
Location
United States
Related Subject Headings
- Urology & Nephrology
- Pyruvate Kinase
- Proteomics
- Mitochondria
- Mice
- Kidney Glomerulus
- Humans
- Diabetic Nephropathies
- Animals
- 3202 Clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Chun, N., Wyatt, C. M., & He, J. C. (2017). Identification of a protective proteomic signature and a potential therapeutic target in diabetic nephropathy. Kidney Int, 92(4), 780–781. https://doi.org/10.1016/j.kint.2017.08.002
Chun, Nicholas, Christina M. Wyatt, and John C. He. “Identification of a protective proteomic signature and a potential therapeutic target in diabetic nephropathy.” Kidney Int 92, no. 4 (October 2017): 780–81. https://doi.org/10.1016/j.kint.2017.08.002.
Chun N, Wyatt CM, He JC. Identification of a protective proteomic signature and a potential therapeutic target in diabetic nephropathy. Kidney Int. 2017 Oct;92(4):780–1.
Chun, Nicholas, et al. “Identification of a protective proteomic signature and a potential therapeutic target in diabetic nephropathy.” Kidney Int, vol. 92, no. 4, Oct. 2017, pp. 780–81. Pubmed, doi:10.1016/j.kint.2017.08.002.
Chun N, Wyatt CM, He JC. Identification of a protective proteomic signature and a potential therapeutic target in diabetic nephropathy. Kidney Int. 2017 Oct;92(4):780–781.
Published In
Kidney Int
DOI
EISSN
1523-1755
Publication Date
October 2017
Volume
92
Issue
4
Start / End Page
780 / 781
Location
United States
Related Subject Headings
- Urology & Nephrology
- Pyruvate Kinase
- Proteomics
- Mitochondria
- Mice
- Kidney Glomerulus
- Humans
- Diabetic Nephropathies
- Animals
- 3202 Clinical sciences