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The burden of dialysis-requiring acute kidney injury among hospitalized adults with HIV infection: a nationwide inpatient sample analysis.

Publication ,  Journal Article
Nadkarni, GN; Patel, AA; Yacoub, R; Benjo, AM; Konstantinidis, I; Annapureddy, N; Agarwal, SK; Simoes, PK; Kamat, S; Menon, MC; Wyatt, CM
Published in: Aids
June 1, 2015

OBJECTIVE: The objective of this study was to describe the incidence of acute kidney injury (AKI) requiring renal replacement therapy ('dialysis-requiring AKI') and the impact on in-hospital mortality among hospitalized adults with HIV infection. DESIGN: A longitudinal analysis of a nationally representative administrative database. METHODS: We reviewed the Healthcare Cost and Utilization Project's Nationwide Inpatient Sample Database, a large, nationally representative sample of inpatient hospital admissions, to identify all adult hospitalizations with an associated diagnosis of HIV infection from 2002 to 2010. We analysed temporal trends in the incidence of dialysis-requiring AKI and the associated odds of in-hospital mortality. We also explored potential reasons behind temporal changes. RESULTS: Among 183 0041 hospitalizations with an associated diagnosis of HIV infection, the proportion complicated by dialysis-requiring AKI increased from 0.7% in 2002 to 1.35% in 2010. This temporal rise was completely explained by changes in demographics and an increase in concurrent comorbidities and procedure utilization. The adjusted odds of in-hospital mortality associated with dialysis-requiring AKI also increased over the study period, from 1.45 [95% confidence interval (95% CI) 0.97-2.12] in 2002 to 2.64 (95% CI 2.04-3.42) in 2010. CONCLUSION: These data suggest that the incidence of dialysis-requiring AKI among hospitalized adults with HIV infection continues to increase, and that severe AKI remains a significant predictor of in-hospital mortality in this population. The increased incidence of dialysis-requiring AKI was largely explained by ageing of the HIV population and increasing prevalence of chronic non-AIDS comorbidities, suggesting that these trends will continue.

Duke Scholars

Published In

Aids

DOI

EISSN

1473-5571

Publication Date

June 1, 2015

Volume

29

Issue

9

Start / End Page

1061 / 1066

Location

England

Related Subject Headings

  • Young Adult
  • Virology
  • United States
  • Survival Analysis
  • Renal Dialysis
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Incidence
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nadkarni, G. N., Patel, A. A., Yacoub, R., Benjo, A. M., Konstantinidis, I., Annapureddy, N., … Wyatt, C. M. (2015). The burden of dialysis-requiring acute kidney injury among hospitalized adults with HIV infection: a nationwide inpatient sample analysis. Aids, 29(9), 1061–1066. https://doi.org/10.1097/QAD.0000000000000653
Nadkarni, Girish N., Achint A. Patel, Rabi Yacoub, Alexandre M. Benjo, Ioannis Konstantinidis, Narender Annapureddy, Shiv Kumar Agarwal, et al. “The burden of dialysis-requiring acute kidney injury among hospitalized adults with HIV infection: a nationwide inpatient sample analysis.Aids 29, no. 9 (June 1, 2015): 1061–66. https://doi.org/10.1097/QAD.0000000000000653.
Nadkarni GN, Patel AA, Yacoub R, Benjo AM, Konstantinidis I, Annapureddy N, et al. The burden of dialysis-requiring acute kidney injury among hospitalized adults with HIV infection: a nationwide inpatient sample analysis. Aids. 2015 Jun 1;29(9):1061–6.
Nadkarni, Girish N., et al. “The burden of dialysis-requiring acute kidney injury among hospitalized adults with HIV infection: a nationwide inpatient sample analysis.Aids, vol. 29, no. 9, June 2015, pp. 1061–66. Pubmed, doi:10.1097/QAD.0000000000000653.
Nadkarni GN, Patel AA, Yacoub R, Benjo AM, Konstantinidis I, Annapureddy N, Agarwal SK, Simoes PK, Kamat S, Menon MC, Wyatt CM. The burden of dialysis-requiring acute kidney injury among hospitalized adults with HIV infection: a nationwide inpatient sample analysis. Aids. 2015 Jun 1;29(9):1061–1066.

Published In

Aids

DOI

EISSN

1473-5571

Publication Date

June 1, 2015

Volume

29

Issue

9

Start / End Page

1061 / 1066

Location

England

Related Subject Headings

  • Young Adult
  • Virology
  • United States
  • Survival Analysis
  • Renal Dialysis
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Incidence
  • Humans