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Effect of bacterial or porcine lipase with low- or high-fat diets on nutrient absorption in pancreatic-insufficient dogs.

Publication ,  Journal Article
Suzuki, A; Mizumoto, A; Rerknimitr, R; Sarr, MG; DiMango, EP
Published in: Gastroenterology
February 1999

BACKGROUND & AIMS: Treatment of human exocrine pancreatic insufficiency is suboptimal. This study assessed the effects of bacterial lipase, porcine lipase, and diets on carbohydrate, fat, and protein absorption in pancreatic-insufficient dogs. METHODS: Dogs were given bacterial or porcine lipase and 3 diets: a 48% carbohydrate, 27% fat, and 25% protein standard diet; a high-carbohydrate, low-fat, and low-protein diet; or a low-carbohydrate, high-fat, and high-protein diet (66%/18%/16% and 21%/43%/36% calories). RESULTS: With the standard diet, coefficient of fat absorption increased dose-dependently with both lipases (P < 0.05), but more fat was absorbed with porcine lipase (P < 0.05); 600, 000 IU of bacterial lipase (240 mg) and 300,000 IU of porcine lipase (18 g) nearly abolished steatorrhea. With 300,000 IU of bacterial lipase or 135,000 IU of porcine lipase, fat absorption was greater with the high-fat and -protein diet (P < 0.05 vs. low-fat and -protein diet). There were no interactions among carbohydrate, fat, and protein absorption. CONCLUSIONS: Correcting steatorrhea requires 75 times more porcine than bacterial lipase (18 vs. 240 mg). High-fat and high-protein diets optimize fat absorption with both enzymes. High-fat diets with bacterial or porcine lipase should be evaluated in humans with pancreatic steatorrhea.

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Published In

Gastroenterology

DOI

ISSN

0016-5085

Publication Date

February 1999

Volume

116

Issue

2

Start / End Page

431 / 437

Location

United States

Related Subject Headings

  • Trypsin
  • Swine
  • Lipase
  • Intestinal Absorption
  • Gastroenterology & Hepatology
  • Exocrine Pancreatic Insufficiency
  • Dose-Response Relationship, Drug
  • Dogs
  • Dietary Proteins
  • Dietary Fats
 

Citation

APA
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Suzuki, A., Mizumoto, A., Rerknimitr, R., Sarr, M. G., & DiMango, E. P. (1999). Effect of bacterial or porcine lipase with low- or high-fat diets on nutrient absorption in pancreatic-insufficient dogs. Gastroenterology, 116(2), 431–437. https://doi.org/10.1016/s0016-5085(99)70141-1
Suzuki, A., A. Mizumoto, R. Rerknimitr, M. G. Sarr, and E. P. DiMango. “Effect of bacterial or porcine lipase with low- or high-fat diets on nutrient absorption in pancreatic-insufficient dogs.Gastroenterology 116, no. 2 (February 1999): 431–37. https://doi.org/10.1016/s0016-5085(99)70141-1.
Suzuki A, Mizumoto A, Rerknimitr R, Sarr MG, DiMango EP. Effect of bacterial or porcine lipase with low- or high-fat diets on nutrient absorption in pancreatic-insufficient dogs. Gastroenterology. 1999 Feb;116(2):431–7.
Suzuki, A., et al. “Effect of bacterial or porcine lipase with low- or high-fat diets on nutrient absorption in pancreatic-insufficient dogs.Gastroenterology, vol. 116, no. 2, Feb. 1999, pp. 431–37. Pubmed, doi:10.1016/s0016-5085(99)70141-1.
Suzuki A, Mizumoto A, Rerknimitr R, Sarr MG, DiMango EP. Effect of bacterial or porcine lipase with low- or high-fat diets on nutrient absorption in pancreatic-insufficient dogs. Gastroenterology. 1999 Feb;116(2):431–437.
Journal cover image

Published In

Gastroenterology

DOI

ISSN

0016-5085

Publication Date

February 1999

Volume

116

Issue

2

Start / End Page

431 / 437

Location

United States

Related Subject Headings

  • Trypsin
  • Swine
  • Lipase
  • Intestinal Absorption
  • Gastroenterology & Hepatology
  • Exocrine Pancreatic Insufficiency
  • Dose-Response Relationship, Drug
  • Dogs
  • Dietary Proteins
  • Dietary Fats