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Effect of bilirubin UDP glucuronosyltransferase 1 gene TATA box genotypes on serum bilirubin concentrations in chronic liver injuries.

Publication ,  Journal Article
Doyama, H; Okada, T; Kobayashi, T; Suzuki, A; Takeda, Y; Mabuchi, H
Published in: Hepatology
September 2000

TATA box abnormality in the promoter region of the bilirubin UDP glucuronosyltransferase 1 gene has been reported to cause Gilbert's syndrome in white subjects. It has also been reported that the majority of Japanese patients with Gilbert's syndrome are heterozygous for Gly71Arg in the coding region of this gene. On the other hand, some patients with chronic hepatitis often show signs of unexpected hyperbilirubinemia. The aims of this study were to determine which of the genetic variations, TATA box genotype or codon 71 genotype, is most closely related to serum bilirubin concentrations, and whether the TATA box genotype has an effect on serum bilirubin concentrations in patients with hepatitis C-associated chronic liver diseases. In a sample of 300 individuals selected from among the general Japanese population, mean concentrations of total serum bilirubin differed significantly among TATA box genotypes, but not among codon 71 genotypes. Concentration of total serum bilirubin was significantly correlated with TATA box genotypes. In 211 patients with hepatitis C-associated chronic liver diseases, mean concentrations of total serum bilirubin also differed significantly among TATA box genotypes. In patients with chronic hepatitis C, concentration of total serum bilirubin was significantly correlated with TATA box genotypes. In summary, TATA box genotypes, but not codon 71 genotypes, are closely related to serum bilirubin concentrations. TATA box genotypes should therefore be considered when evaluating hepatic function by serum bilirubin concentrations in cases of hepatitis C-associated chronic liver diseases.

Duke Scholars

Published In

Hepatology

DOI

ISSN

0270-9139

Publication Date

September 2000

Volume

32

Issue

3

Start / End Page

563 / 568

Location

United States

Related Subject Headings

  • TATA Box
  • Reference Values
  • Osmolar Concentration
  • Mutation
  • Middle Aged
  • Male
  • Liver Cirrhosis
  • Isoenzymes
  • Humans
  • Hepatitis C, Chronic
 

Citation

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ICMJE
MLA
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Doyama, H., Okada, T., Kobayashi, T., Suzuki, A., Takeda, Y., & Mabuchi, H. (2000). Effect of bilirubin UDP glucuronosyltransferase 1 gene TATA box genotypes on serum bilirubin concentrations in chronic liver injuries. Hepatology, 32(3), 563–568. https://doi.org/10.1053/jhep.2000.16331
Journal cover image

Published In

Hepatology

DOI

ISSN

0270-9139

Publication Date

September 2000

Volume

32

Issue

3

Start / End Page

563 / 568

Location

United States

Related Subject Headings

  • TATA Box
  • Reference Values
  • Osmolar Concentration
  • Mutation
  • Middle Aged
  • Male
  • Liver Cirrhosis
  • Isoenzymes
  • Humans
  • Hepatitis C, Chronic