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Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels.

Publication ,  Journal Article
Matano, Y; Okada, T; Suzuki, A; Yoneda, T; Takeda, Y; Mabuchi, H
Published in: Am J Gastroenterol
May 2005

OBJECTIVES: Acromegalics have been reported to be at an increased risk of colorectal neoplasm. However, the magnitude of the risk is still controversial and the mechanism has not been fully investigated. In this study, we attempted to determine the magnitude of the association between acromegaly and colorectal lesions after taking into account age, gender, smoking status, and treatment status. In addition, we assessed the relationship between colorectal lesions and serum growth hormone (GH) levels in acromegalics. METHODS: We conducted a case-control study by using 19 consecutive untreated patients (male:female = 11:8) who were newly diagnosed with acromegaly between 1990 and 2000. All patients underwent colonoscopy and received a histological diagnosis of colorectal lesions. Prevalence of hyperplastic polyp, adenoma, and carcinoma were compared with the prevalence in 76 controls matched for gender, age, and smoking status. Serum GH levels were compared between acromegalic patients with and without each type of colorectal lesion. RESULTS: The prevalence of hyperplastic polyp, adenoma, and carcinoma were significantly higher in the acromegalic patients compared to the controls (p < 0.05, odds ratios; 8.3, 4.2, and 9.8, respectively). In acromegalics, the presence of hyperplastic polyps and carcinomas were significantly associated with higher serum GH levels after adjusting for the other lesions and age (p < 0.05). CONCLUSIONS: After controlling for age, gender, smoking status, and treatment status, acromegaly was associated with significantly higher prevalence of colorectal hyperplastic polyp, adenoma, and carcinoma. High serum GH levels may be associated with the presence of hyperplastic polyp and carcinoma.

Duke Scholars

Published In

Am J Gastroenterol

DOI

ISSN

0002-9270

Publication Date

May 2005

Volume

100

Issue

5

Start / End Page

1154 / 1160

Location

United States

Related Subject Headings

  • Smoking
  • Sex Factors
  • Risk Factors
  • Rectal Neoplasms
  • Middle Aged
  • Male
  • Intestinal Polyps
  • Hyperplasia
  • Humans
  • Human Growth Hormone
 

Citation

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Chicago
ICMJE
MLA
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Matano, Y., Okada, T., Suzuki, A., Yoneda, T., Takeda, Y., & Mabuchi, H. (2005). Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels. Am J Gastroenterol, 100(5), 1154–1160. https://doi.org/10.1111/j.1572-0241.2005.40808.x
Matano, Yutaka, Toshihide Okada, Ayako Suzuki, Takashi Yoneda, Yoshiyun Takeda, and Hiroshi Mabuchi. “Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels.Am J Gastroenterol 100, no. 5 (May 2005): 1154–60. https://doi.org/10.1111/j.1572-0241.2005.40808.x.
Matano Y, Okada T, Suzuki A, Yoneda T, Takeda Y, Mabuchi H. Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels. Am J Gastroenterol. 2005 May;100(5):1154–60.
Matano, Yutaka, et al. “Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels.Am J Gastroenterol, vol. 100, no. 5, May 2005, pp. 1154–60. Pubmed, doi:10.1111/j.1572-0241.2005.40808.x.
Matano Y, Okada T, Suzuki A, Yoneda T, Takeda Y, Mabuchi H. Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels. Am J Gastroenterol. 2005 May;100(5):1154–1160.
Journal cover image

Published In

Am J Gastroenterol

DOI

ISSN

0002-9270

Publication Date

May 2005

Volume

100

Issue

5

Start / End Page

1154 / 1160

Location

United States

Related Subject Headings

  • Smoking
  • Sex Factors
  • Risk Factors
  • Rectal Neoplasms
  • Middle Aged
  • Male
  • Intestinal Polyps
  • Hyperplasia
  • Humans
  • Human Growth Hormone