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Quality of life and mood of older patients with acute myeloid leukemia (AML) receiving intensive and non-intensive chemotherapy.

Publication ,  Journal Article
El-Jawahri, A; Abel, GA; Traeger, L; Waldman, L; Markovitz, N; VanDusen, H; Fathi, A; Steensma, DP; LeBlanc, TW; Horick, NK; DeAngelo, DJ ...
Published in: Leukemia
October 2019

Older patients with AML face difficult treatment decisions as they can be treated either with 'intensive' chemotherapy requiring prolonged hospitalization, or 'non-intensive' chemotherapy. Although clinicians often perceive intensive chemotherapy as more burdensome, research is lacking on patients' quality of life (QOL) and psychological distress. We conducted a longitudinal study of older patients (≥60 years) newly diagnosed with AML receiving intensive (cytarabine/anthracycline combination) or non-intensive (hypomethylating agents) chemotherapy. We assessed patients' QOL [Functional-Assessment-of-Cancer-Therapy-Leukemia] and psychological distress [Hospital-Anxiety-and-Depression-Scale] at baseline and 2, 4, 8, 12, and 24 weeks after diagnosis. We enrolled 75.2% (100/133) of eligible patients within 72-hours of initiating intensive (n = 50) or non-intensive (n = 50) chemotherapy. Patient QOL improved over time (β = 0.32, P = 0.013). At baseline, 33.3% (33/100) and 30.0% (30/100) of patients reported clinically significant depression and anxiety symptoms, respectively, with no differences between groups. Patients' depression symptoms did not change over time, while their anxiety symptoms decreased over time (β = -0.08, P < 0.001). Patient-reported QOL, depression and anxiety symptoms did not differ significantly at any time point between those who received intensive versus non-intensive chemotherapy. Older patients with AML experience improvements in their QOL and anxiety while undergoing treatment. Patients receiving intensive and non-intensive chemotherapy have similar QOL and mood trajectories.

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Published In

Leukemia

DOI

EISSN

1476-5551

Publication Date

October 2019

Volume

33

Issue

10

Start / End Page

2393 / 2402

Location

England

Related Subject Headings

  • Quality of Life
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Leukemia, Myeloid, Acute
  • Immunology
  • Humans
  • Female
  • Depression
  • Cytarabine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
El-Jawahri, A., Abel, G. A., Traeger, L., Waldman, L., Markovitz, N., VanDusen, H., … Greer, J. A. (2019). Quality of life and mood of older patients with acute myeloid leukemia (AML) receiving intensive and non-intensive chemotherapy. Leukemia, 33(10), 2393–2402. https://doi.org/10.1038/s41375-019-0449-1
El-Jawahri, Areej, Gregory A. Abel, Lara Traeger, Lauren Waldman, Netana Markovitz, Harry VanDusen, Amir Fathi, et al. “Quality of life and mood of older patients with acute myeloid leukemia (AML) receiving intensive and non-intensive chemotherapy.Leukemia 33, no. 10 (October 2019): 2393–2402. https://doi.org/10.1038/s41375-019-0449-1.
El-Jawahri A, Abel GA, Traeger L, Waldman L, Markovitz N, VanDusen H, et al. Quality of life and mood of older patients with acute myeloid leukemia (AML) receiving intensive and non-intensive chemotherapy. Leukemia. 2019 Oct;33(10):2393–402.
El-Jawahri, Areej, et al. “Quality of life and mood of older patients with acute myeloid leukemia (AML) receiving intensive and non-intensive chemotherapy.Leukemia, vol. 33, no. 10, Oct. 2019, pp. 2393–402. Pubmed, doi:10.1038/s41375-019-0449-1.
El-Jawahri A, Abel GA, Traeger L, Waldman L, Markovitz N, VanDusen H, Fathi A, Steensma DP, LeBlanc TW, Horick NK, DeAngelo DJ, Wadleigh M, Hobbs G, Foster J, Brunner AM, Amrein P, Stone RM, Temel JS, Greer JA. Quality of life and mood of older patients with acute myeloid leukemia (AML) receiving intensive and non-intensive chemotherapy. Leukemia. 2019 Oct;33(10):2393–2402.

Published In

Leukemia

DOI

EISSN

1476-5551

Publication Date

October 2019

Volume

33

Issue

10

Start / End Page

2393 / 2402

Location

England

Related Subject Headings

  • Quality of Life
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Leukemia, Myeloid, Acute
  • Immunology
  • Humans
  • Female
  • Depression
  • Cytarabine