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Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium.

Publication ,  Journal Article
Kelleher, AM; Behura, SK; Burns, GW; Young, SL; DeMayo, FJ; Spencer, TE
Published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
July 2019

The pioneer forkhead box (FOX)A2 transcription factor is specifically expressed in the glands of the uterus, which are central to endometrial function and fertility. In mice, FOXA2 is a critical regulator of uterine gland development in the neonate and gland function in the adult. An integrative approach was used here to define the FOXA2 cistrome in the human endometrium. Genome-wide mapping of FOXA2 binding intervals by chromatin immunoprecipitation sequencing was performed using proliferative (P)- and midsecretory (MS)-phase endometrium and integrated with the transcriptome determined by RNA sequencing. Distinctive FOXA2 binding intervals, enriched for different transcription factor binding site motifs, were detected in the P and MS endometrium. Pathway analysis revealed different biologic processes regulated by genes with FOXA2 binding intervals in the P and MS endometrium. Thus, FOXA2 is postulated to regulate gene expression in concert with other transcription factors and impact uterine gland development and function in a cycle phase-dependent manner. Analyses also identified potential FOXA2-regulated genes that influence uterine receptivity, blastocyst implantation, and stromal cell decidualization, which are key events in pregnancy establishment.-Kelleher, A. M., Behura, S. K., Burns, G. W., Young, S. L., DeMayo, F. J., Spencer, T. E. Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium.

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Published In

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

DOI

EISSN

1530-6860

ISSN

0892-6638

Publication Date

July 2019

Volume

33

Issue

7

Start / End Page

8543 / 8554

Related Subject Headings

  • Young Adult
  • Uterus
  • Transcription Factors
  • Stromal Cells
  • Pregnancy
  • Humans
  • Hepatocyte Nuclear Factor 3-beta
  • Gene Expression Regulation
  • Fertility
  • Female
 

Citation

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Kelleher, A. M., Behura, S. K., Burns, G. W., Young, S. L., DeMayo, F. J., & Spencer, T. E. (2019). Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 33(7), 8543–8554. https://doi.org/10.1096/fj.201900013r
Kelleher, Andrew M., Susanta K. Behura, Gregory W. Burns, Steven L. Young, Francesco J. DeMayo, and Thomas E. Spencer. “Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium.FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 33, no. 7 (July 2019): 8543–54. https://doi.org/10.1096/fj.201900013r.
Kelleher AM, Behura SK, Burns GW, Young SL, DeMayo FJ, Spencer TE. Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 Jul;33(7):8543–54.
Kelleher, Andrew M., et al. “Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium.FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, vol. 33, no. 7, July 2019, pp. 8543–54. Epmc, doi:10.1096/fj.201900013r.
Kelleher AM, Behura SK, Burns GW, Young SL, DeMayo FJ, Spencer TE. Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 Jul;33(7):8543–8554.

Published In

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

DOI

EISSN

1530-6860

ISSN

0892-6638

Publication Date

July 2019

Volume

33

Issue

7

Start / End Page

8543 / 8554

Related Subject Headings

  • Young Adult
  • Uterus
  • Transcription Factors
  • Stromal Cells
  • Pregnancy
  • Humans
  • Hepatocyte Nuclear Factor 3-beta
  • Gene Expression Regulation
  • Fertility
  • Female