A Machine-Learning-Based Drug Repurposing Approach Using Baseline Regularization.
Publication
, Chapter
Kuang, Z; Bao, Y; Thomson, J; Caldwell, M; Peissig, P; Stewart, R; Willett, R; Page, D
2019
We present the baseline regularization model for computational drug repurposing using electronic health records (EHRs). In EHRs, drug prescriptions of various drugs are recorded throughout time for various patients. In the same time, numeric physical measurements (e.g., fasting blood glucose level) are also recorded. Baseline regularization uses statistical relationships between the occurrences of prescriptions of some particular drugs and the increase or the decrease in the values of some particular numeric physical measurements to identify potential repurposing opportunities.
Duke Scholars
DOI
Publication Date
2019
Volume
1903
Start / End Page
255 / 267
Related Subject Headings
- Machine Learning
- Humans
- Electronic Health Records
- Drug Repositioning
- Developmental Biology
- Computational Biology
- Algorithms
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Kuang, Z., Bao, Y., Thomson, J., Caldwell, M., Peissig, P., Stewart, R., … Page, D. (2019). A Machine-Learning-Based Drug Repurposing Approach Using Baseline Regularization. (Vol. 1903, pp. 255–267). https://doi.org/10.1007/978-1-4939-8955-3_15
Kuang, Zhaobin, Yujia Bao, James Thomson, Michael Caldwell, Peggy Peissig, Ron Stewart, Rebecca Willett, and David Page. “A Machine-Learning-Based Drug Repurposing Approach Using Baseline Regularization.,” 1903:255–67, 2019. https://doi.org/10.1007/978-1-4939-8955-3_15.
Kuang Z, Bao Y, Thomson J, Caldwell M, Peissig P, Stewart R, et al. A Machine-Learning-Based Drug Repurposing Approach Using Baseline Regularization. In 2019. p. 255–67.
Kuang, Zhaobin, et al. A Machine-Learning-Based Drug Repurposing Approach Using Baseline Regularization. Vol. 1903, 2019, pp. 255–67. Pubmed, doi:10.1007/978-1-4939-8955-3_15.
Kuang Z, Bao Y, Thomson J, Caldwell M, Peissig P, Stewart R, Willett R, Page D. A Machine-Learning-Based Drug Repurposing Approach Using Baseline Regularization. 2019. p. 255–267.
DOI
Publication Date
2019
Volume
1903
Start / End Page
255 / 267
Related Subject Headings
- Machine Learning
- Humans
- Electronic Health Records
- Drug Repositioning
- Developmental Biology
- Computational Biology
- Algorithms
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology