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A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays.

Publication ,  Journal Article
Chhatbar, PY; von Kraus, LM; Semework, M; Francis, JT
Published in: J Neurosci Methods
May 15, 2010

Many neurophysiological experiments on rodents and non-human primates involve the implantation of more than one multi-electrode array to record from many regions of the brain. So called 'floating' microelectrode arrays are implanted in cortical regions of interest and are coupled via a flexible cable to their connectors which are fixed to the skull by a cement cap or a titanium pedestal, such as the Cereport system, which has been approved for human use. The use of bone cement has several disadvantages including the creation of infection prone areas at the interface with the skull and surrounding skin. Alternatively, the more biocompatible Cereport has a limited carrying capacity and is far more expensive. In this paper, we describe a new implantation technique, which combines the biocompatibility of titanium, a high carrying capacity with a minimal skull footprint, and a decreased chance of infection, all in a relatively inexpensive package. This technique utilizes an in-house fabricated 'Nesting Platform' (NP), mounted on a titanium headpost to hold multiple connectors above the skin, making the headpost the only transcutaneous object. The use of delrin, a durable, lightweight and easily machinable material, allows easy customization of the NP for a wide variety of floating electrodes and their connectors. The ultimate result is a longer survival time with superior neural recordings that can potentially last longer than with traditional implantation techniques.

Duke Scholars

Published In

J Neurosci Methods

DOI

EISSN

1872-678X

Publication Date

May 15, 2010

Volume

188

Issue

2

Start / End Page

187 / 194

Location

Netherlands

Related Subject Headings

  • Titanium
  • Resins, Synthetic
  • Prosthesis Implantation
  • Neurosurgical Procedures
  • Neurophysiology
  • Neurons
  • Neurology & Neurosurgery
  • Models, Animal
  • Microelectrodes
  • Macaca radiata
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chhatbar, P. Y., von Kraus, L. M., Semework, M., & Francis, J. T. (2010). A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays. J Neurosci Methods, 188(2), 187–194. https://doi.org/10.1016/j.jneumeth.2010.02.006
Chhatbar, Pratik Y., Lee M. von Kraus, Mulugeta Semework, and Joseph T. Francis. “A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays.J Neurosci Methods 188, no. 2 (May 15, 2010): 187–94. https://doi.org/10.1016/j.jneumeth.2010.02.006.
Chhatbar PY, von Kraus LM, Semework M, Francis JT. A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays. J Neurosci Methods. 2010 May 15;188(2):187–94.
Chhatbar, Pratik Y., et al. “A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays.J Neurosci Methods, vol. 188, no. 2, May 2010, pp. 187–94. Pubmed, doi:10.1016/j.jneumeth.2010.02.006.
Chhatbar PY, von Kraus LM, Semework M, Francis JT. A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays. J Neurosci Methods. 2010 May 15;188(2):187–194.
Journal cover image

Published In

J Neurosci Methods

DOI

EISSN

1872-678X

Publication Date

May 15, 2010

Volume

188

Issue

2

Start / End Page

187 / 194

Location

Netherlands

Related Subject Headings

  • Titanium
  • Resins, Synthetic
  • Prosthesis Implantation
  • Neurosurgical Procedures
  • Neurophysiology
  • Neurons
  • Neurology & Neurosurgery
  • Models, Animal
  • Microelectrodes
  • Macaca radiata