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Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension.

Publication ,  Journal Article
Chua, J; Chin, CWL; Tan, B; Wong, SH; Devarajan, K; Le, T-T; Ang, M; Wong, TY; Schmetterer, L
Published in: Sci Rep
April 9, 2019

We investigated the characteristics of the choriocapillaris flow voids using optical coherence tomography angiography (OCTA) in 85 patients (164 eyes) with hypertension (mean ± SD age, 56 ± 11 years; 45% women; 20% poorly controlled BP; 16% diabetes) who are without ocular diseases and determined possible correlations with systemic vascular risk factors. Data on 24-hour ambulatory blood pressure (BP), serum creatinine, and urine microalbumin/creatinine ratio (MCR) were collected. Estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. OCTA imaging (6 × 6 mm scans; AngioVue) with quantitative microvascular analysis of the choriocapillaris was performed. Linear regression was used to investigate the association of systemic risk factors with area (percentage), size (pixels) and number of choriocapillaris flow voids. Diabetes (β = 0.33; 95% CI, 0.02 to 0.63) and daytime systolic BP (β = -0.13; 95% CI, -0.24 to -0.02) were associated with areas of flow voids. Age (β = 0.21; 95% CI, 0.06 to 0.36) and daytime diastolic BP (β = -0.18; 95% CI, -0.34 to -0.02) were associated with size of flow voids. Age (β = -21.21; 95% CI, -31.79 to -10.63) and nighttime diastolic BP (β = 13.89; 95% CI, 0.61 to 27.17) were associated with number of flow voids. Kidney parameters were not associated with any features of flow voids. In patients with hypertension, a higher BP appeared to increase blood flow in the choriocapillaris which needs to be considered when using the OCTA to study eye diseases in hypertensives.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

April 9, 2019

Volume

9

Issue

1

Start / End Page

5819

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Risk Factors
  • Middle Aged
  • Male
  • Macular Degeneration
  • Hypertension
  • Humans
  • Glomerular Filtration Rate
  • Female
  • Eye Diseases
 

Citation

APA
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ICMJE
MLA
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Chua, J., Chin, C. W. L., Tan, B., Wong, S. H., Devarajan, K., Le, T.-T., … Schmetterer, L. (2019). Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension. Sci Rep, 9(1), 5819. https://doi.org/10.1038/s41598-019-41917-4
Chua, Jacqueline, Calvin Woon Loong Chin, Bingyao Tan, Si Han Wong, Kavya Devarajan, Thu-Thao Le, Marcus Ang, Tien Yin Wong, and Leopold Schmetterer. “Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension.Sci Rep 9, no. 1 (April 9, 2019): 5819. https://doi.org/10.1038/s41598-019-41917-4.
Chua, Jacqueline, et al. “Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension.Sci Rep, vol. 9, no. 1, Apr. 2019, p. 5819. Pubmed, doi:10.1038/s41598-019-41917-4.
Chua J, Chin CWL, Tan B, Wong SH, Devarajan K, Le T-T, Ang M, Wong TY, Schmetterer L. Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension. Sci Rep. 2019 Apr 9;9(1):5819.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

April 9, 2019

Volume

9

Issue

1

Start / End Page

5819

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Risk Factors
  • Middle Aged
  • Male
  • Macular Degeneration
  • Hypertension
  • Humans
  • Glomerular Filtration Rate
  • Female
  • Eye Diseases