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The Association Between Conversion to In-centre Nocturnal Hemodialysis and Left Ventricular Mass Regression in Patients With End-Stage Renal Disease.

Publication ,  Journal Article
Wald, R; Goldstein, MB; Perl, J; Kiaii, M; Yuen, D; Wald, RM; Harel, Z; Weinstein, JJ; Jakubovic, B; Leong-Poi, H; Kirpalani, A; Leipsic, J ...
Published in: Can J Cardiol
March 2016

BACKGROUND: In-centre nocturnal hemodialysis (INHD, 7-8 hours/session, 3 times/week) is an increasingly utilized form of dialysis intensification, though data on the cardiovascular benefits of this modality are limited. METHODS: In this prospective cohort study, we enrolled 67 prevalent conventional hemodialysis (CHD, 4 hours/session, 3 times/week) recipients at 2 medical centres in Canada, of whom 37 converted to INHD and 30 remained on CHD. The primary outcome was the change in left ventricular mass (LVM) after 1 year as assessed by cardiac magnetic resonance imaging. Secondary outcomes included changes in serum phosphate concentration, phosphate binder burden, haemoglobin, erythropoiesis stimulating agent usage, and blood pressure. RESULTS: Conversion to INHD was associated with a 14.2 (95% confidence interval [CI] 1.2-27.2) g reduction in LVM as compared with continuation on CHD. This result was maintained after adjustment for baseline imbalances between the groups and in ancillary analyses. There was a trend toward a larger drop in systolic blood pressure (9.8 [95% CI, -1.4-20.9] mm Hg) among INHD recipients with a significant reduction in the number of prescribed antihypertensive agents (0.7 [95% CI, 0.3-1.1] agents). Serum phosphate declined by 0.40 (95% CI, 0.16-0.63) mmol/L among INHD recipients without any difference in calcium-based phosphate binder requirements, as compared with those who remained on CHD. CONCLUSIONS: Compared with continuation of CHD, conversion to INHD was associated with significant LVM regression and reduction in serum phosphate concentration at 1 year.

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Published In

Can J Cardiol

DOI

EISSN

1916-7075

Publication Date

March 2016

Volume

32

Issue

3

Start / End Page

369 / 377

Location

England

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Time Factors
  • Renal Dialysis
  • Prospective Studies
  • Phosphates
  • Ontario
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging, Cine
 

Citation

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Chicago
ICMJE
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Wald, R., Goldstein, M. B., Perl, J., Kiaii, M., Yuen, D., Wald, R. M., … Yan, A. T. (2016). The Association Between Conversion to In-centre Nocturnal Hemodialysis and Left Ventricular Mass Regression in Patients With End-Stage Renal Disease. Can J Cardiol, 32(3), 369–377. https://doi.org/10.1016/j.cjca.2015.07.004
Wald, Ron, Marc B. Goldstein, Jeffrey Perl, Mercedeh Kiaii, Darren Yuen, Rachel M. Wald, Ziv Harel, et al. “The Association Between Conversion to In-centre Nocturnal Hemodialysis and Left Ventricular Mass Regression in Patients With End-Stage Renal Disease.Can J Cardiol 32, no. 3 (March 2016): 369–77. https://doi.org/10.1016/j.cjca.2015.07.004.
Wald R, Goldstein MB, Perl J, Kiaii M, Yuen D, Wald RM, et al. The Association Between Conversion to In-centre Nocturnal Hemodialysis and Left Ventricular Mass Regression in Patients With End-Stage Renal Disease. Can J Cardiol. 2016 Mar;32(3):369–77.
Wald, Ron, et al. “The Association Between Conversion to In-centre Nocturnal Hemodialysis and Left Ventricular Mass Regression in Patients With End-Stage Renal Disease.Can J Cardiol, vol. 32, no. 3, Mar. 2016, pp. 369–77. Pubmed, doi:10.1016/j.cjca.2015.07.004.
Wald R, Goldstein MB, Perl J, Kiaii M, Yuen D, Wald RM, Harel Z, Weinstein JJ, Jakubovic B, Leong-Poi H, Kirpalani A, Leipsic J, Dacouris N, Wolf M, Yan AT. The Association Between Conversion to In-centre Nocturnal Hemodialysis and Left Ventricular Mass Regression in Patients With End-Stage Renal Disease. Can J Cardiol. 2016 Mar;32(3):369–377.

Published In

Can J Cardiol

DOI

EISSN

1916-7075

Publication Date

March 2016

Volume

32

Issue

3

Start / End Page

369 / 377

Location

England

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Time Factors
  • Renal Dialysis
  • Prospective Studies
  • Phosphates
  • Ontario
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging, Cine