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Impact of westernization on fibroblast growth factor 23 levels among individuals of African ancestry.

Publication ,  Journal Article
Eckberg, K; Kramer, H; Wolf, M; Durazo-Arvizu, R; Tayo, B; Luke, A; Cooper, R
Published in: Nephrol Dial Transplant
April 2015

INTRODUCTION: The Western diet is associated with high consumption of processed foods preserved with phosphate. Higher dietary phosphate consumption stimulates production of fibroblast growth factor 23 (FGF23), which heightens risk for cardiovascular disease and mortality. We hypothesized that adults living in a more westernized society have higher levels of FGF23 due to increased phosphate consumption as measured by urinary phosphate excretion. METHODS: We measured plasma C-terminal FGF23 levels and urinary phosphate and creatinine levels in timed urine collections among 100 African adults living in the rural area of Igbo-Ora, Nigeria (52 women, 48 men), and 100 African Americans (32 women, 68 men) living in Maywood, IL, an urban suburb of Chicago, IL, USA. Among these 200 participants, urine collections were adequate in 76 and 68 of the Maywood and Igbo-Ora participants, respectively. RESULTS: In the total group, the mean age and body mass index, respectively, were 34.6 ± 8.2 years and 22.1 ± 3.9 kg/m(2) in Igbo-Ora, and 42.8 ± 7.2 years and 25.8 ± 6.5 kg/m(2) in Maywood. Demographic characteristics for each site were very similar after excluding participants without adequate urine collections. Among all 200 participants, the median (interquartile range) FGF23 levels were significantly higher in Maywood versus Igbo-Ora [63.8 (45.0-89.9) versus 12.5 RU/mL (8.5-18.5); P < 0.0001] and these differences did not change substantially after excluding nine women from Maywood with FGF23 levels >400 RU/mL or after excluding participants with inadequate urine collections. Among participants with adequate urine collections, the mean 24-h urinary phosphate excretion was significantly higher in Maywood versus Igbo-Ora (810.6 ± 309.0 versus 347.5 ± 153.1 mg; P < 0.001) and FGF23 levels correlated significantly with total urinary phosphate excretion (r = 0.62; P < 0.001) and urinary phosphate-to-creatinine ratios (r = 0.50; P < 0.001). CONCLUSIONS: Living in a more westernized society may be associated with greater net phosphate absorption, as reflected by higher urinary phosphate excretion, and higher FGF23 levels.

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Published In

Nephrol Dial Transplant

DOI

EISSN

1460-2385

Publication Date

April 2015

Volume

30

Issue

4

Start / End Page

630 / 635

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Urinalysis
  • United States
  • Phosphates
  • Nigeria
  • Male
  • Humans
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Female
 

Citation

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Eckberg, K., Kramer, H., Wolf, M., Durazo-Arvizu, R., Tayo, B., Luke, A., & Cooper, R. (2015). Impact of westernization on fibroblast growth factor 23 levels among individuals of African ancestry. Nephrol Dial Transplant, 30(4), 630–635. https://doi.org/10.1093/ndt/gfu342
Eckberg, Karl, Holly Kramer, Myles Wolf, Ramon Durazo-Arvizu, Bamidele Tayo, Amy Luke, and Richard Cooper. “Impact of westernization on fibroblast growth factor 23 levels among individuals of African ancestry.Nephrol Dial Transplant 30, no. 4 (April 2015): 630–35. https://doi.org/10.1093/ndt/gfu342.
Eckberg K, Kramer H, Wolf M, Durazo-Arvizu R, Tayo B, Luke A, et al. Impact of westernization on fibroblast growth factor 23 levels among individuals of African ancestry. Nephrol Dial Transplant. 2015 Apr;30(4):630–5.
Eckberg, Karl, et al. “Impact of westernization on fibroblast growth factor 23 levels among individuals of African ancestry.Nephrol Dial Transplant, vol. 30, no. 4, Apr. 2015, pp. 630–35. Pubmed, doi:10.1093/ndt/gfu342.
Eckberg K, Kramer H, Wolf M, Durazo-Arvizu R, Tayo B, Luke A, Cooper R. Impact of westernization on fibroblast growth factor 23 levels among individuals of African ancestry. Nephrol Dial Transplant. 2015 Apr;30(4):630–635.
Journal cover image

Published In

Nephrol Dial Transplant

DOI

EISSN

1460-2385

Publication Date

April 2015

Volume

30

Issue

4

Start / End Page

630 / 635

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Urinalysis
  • United States
  • Phosphates
  • Nigeria
  • Male
  • Humans
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Female