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Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury.

Publication ,  Journal Article
Leaf, DE; Wolf, M; Stern, L
Published in: Nephrol Dial Transplant
April 2010

Rhabdomyolysis-induced acute kidney injury (AKI) is characterized by hyperphosphataemia and hypocalcaemia. Despite appropriate secondary elevation of parathyroid hormone (PTH) in response to hypocalcaemia, rhabdomyolysis and AKI are associated with acute deficiency of 1,25-dihydroxycholecalciferol (1,25(OH)(2)D(3)), and yet, the mechanism responsible for such a deficiency remains unclear. Fibroblast growth factor 23 (FGF-23), a potent phosphaturic hormone that inhibits 25-hydroxyvitamin D(3)-1alpha-hydroxylase, could explain the deficiency of 1,25(OH)(2)D(3) in this setting. Here, we document, for the first time, elevated levels of FGF-23 in a patient with rhabdomyolysis-induced AKI.

Duke Scholars

Published In

Nephrol Dial Transplant

DOI

EISSN

1460-2385

Publication Date

April 2010

Volume

25

Issue

4

Start / End Page

1335 / 1337

Location

England

Related Subject Headings

  • Vitamin D
  • Urology & Nephrology
  • Rhabdomyolysis
  • Prognosis
  • Middle Aged
  • Male
  • Humans
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Acute Kidney Injury
 

Citation

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Leaf, D. E., Wolf, M., & Stern, L. (2010). Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury. Nephrol Dial Transplant, 25(4), 1335–1337. https://doi.org/10.1093/ndt/gfp682
Leaf, David E., Myles Wolf, and Leonard Stern. “Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury.Nephrol Dial Transplant 25, no. 4 (April 2010): 1335–37. https://doi.org/10.1093/ndt/gfp682.
Leaf DE, Wolf M, Stern L. Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury. Nephrol Dial Transplant. 2010 Apr;25(4):1335–7.
Leaf, David E., et al. “Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury.Nephrol Dial Transplant, vol. 25, no. 4, Apr. 2010, pp. 1335–37. Pubmed, doi:10.1093/ndt/gfp682.
Leaf DE, Wolf M, Stern L. Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury. Nephrol Dial Transplant. 2010 Apr;25(4):1335–1337.
Journal cover image

Published In

Nephrol Dial Transplant

DOI

EISSN

1460-2385

Publication Date

April 2010

Volume

25

Issue

4

Start / End Page

1335 / 1337

Location

England

Related Subject Headings

  • Vitamin D
  • Urology & Nephrology
  • Rhabdomyolysis
  • Prognosis
  • Middle Aged
  • Male
  • Humans
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Acute Kidney Injury