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Associations Between Slower Walking Speed and T1ρ Magnetic Resonance Imaging of Femoral Cartilage Following Anterior Cruciate Ligament Reconstruction.

Publication ,  Journal Article
Pfeiffer, S; Harkey, MS; Stanley, LE; Blackburn, JT; Padua, DA; Spang, JT; Marshall, SW; Jordan, JM; Schmitz, R; Nissman, D; Pietrosimone, B
Published in: Arthritis Care Res (Hoboken)
August 2018

OBJECTIVE: To determine whether walking speed, collected at 6 and 12 months following anterior cruciate ligament reconstruction (ACLR), is associated with inter-extremity differences in proteoglycan density, measured via T1ρ magnetic resonance imaging, in tibiofemoral articular cartilage 12 months following ACLR. METHODS: Twenty-one individuals with a unilateral patellar-tendon autograft ACLR (10 women and 11 men, mean ± SD age 23.9 ± 2.7 years, mean ± SD body mass index 23.9 ± 2.7 kg/m2 ) were recruited for participation in this study. Walking speed was collected using 3-dimensional motion capture at 6 and 12 months following ACLR. The articular cartilage of the medial femoral condyle (MFC) and lateral femoral condyle and medial and lateral tibial condyles was manually segmented and subsectioned into 3 regions of interest (anterior, central, and posterior) based on the location of the meniscus in the sagittal plane. Inter-extremity mean T1ρ relaxation time ratios (T1ρ ACLR extremity / T1ρ contralateral extremity) were calculated and used for analysis. Pearson product-moment correlations were used to determine associations between walking speed and inter-extremity differences in T1ρ relaxation time ratios. RESULTS: Slower walking speed 6 months post-ACLR was significantly associated with higher T1ρ relaxation time ratios in the MFC of the ACLR extremity 12 months following ACLR (posterior MFC, r = -0.51, P = 0.02; central MFC, r = -0.47, P = 0.04). Similarly, slower walking speed at 12 months post-ACLR was significantly associated with higher T1ρ relaxation time ratios in the posterior MFC ACLR extremity (r = -0.47, P = 0.04) 12 months following ACLR. CONCLUSION: Slower walking speed at 6 and 12 months following ACLR may be associated with early proteoglycan density changes in medial femoral compartment cartilage health in the first 12 months following ACLR.

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Published In

Arthritis Care Res (Hoboken)

DOI

EISSN

2151-4658

Publication Date

August 2018

Volume

70

Issue

8

Start / End Page

1132 / 1140

Location

United States

Related Subject Headings

  • Young Adult
  • Walking Speed
  • Treatment Outcome
  • Time Factors
  • Sex Factors
  • Recovery of Function
  • Male
  • Magnetic Resonance Imaging
  • Injury Severity Score
  • Imaging, Three-Dimensional
 

Citation

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Pfeiffer, S., Harkey, M. S., Stanley, L. E., Blackburn, J. T., Padua, D. A., Spang, J. T., … Pietrosimone, B. (2018). Associations Between Slower Walking Speed and T1ρ Magnetic Resonance Imaging of Femoral Cartilage Following Anterior Cruciate Ligament Reconstruction. Arthritis Care Res (Hoboken), 70(8), 1132–1140. https://doi.org/10.1002/acr.23477
Pfeiffer, Steven, Matthew S. Harkey, Laura E. Stanley, J Troy Blackburn, Darin A. Padua, Jeffrey T. Spang, Stephen W. Marshall, et al. “Associations Between Slower Walking Speed and T1ρ Magnetic Resonance Imaging of Femoral Cartilage Following Anterior Cruciate Ligament Reconstruction.Arthritis Care Res (Hoboken) 70, no. 8 (August 2018): 1132–40. https://doi.org/10.1002/acr.23477.
Pfeiffer S, Harkey MS, Stanley LE, Blackburn JT, Padua DA, Spang JT, et al. Associations Between Slower Walking Speed and T1ρ Magnetic Resonance Imaging of Femoral Cartilage Following Anterior Cruciate Ligament Reconstruction. Arthritis Care Res (Hoboken). 2018 Aug;70(8):1132–40.
Pfeiffer, Steven, et al. “Associations Between Slower Walking Speed and T1ρ Magnetic Resonance Imaging of Femoral Cartilage Following Anterior Cruciate Ligament Reconstruction.Arthritis Care Res (Hoboken), vol. 70, no. 8, Aug. 2018, pp. 1132–40. Pubmed, doi:10.1002/acr.23477.
Pfeiffer S, Harkey MS, Stanley LE, Blackburn JT, Padua DA, Spang JT, Marshall SW, Jordan JM, Schmitz R, Nissman D, Pietrosimone B. Associations Between Slower Walking Speed and T1ρ Magnetic Resonance Imaging of Femoral Cartilage Following Anterior Cruciate Ligament Reconstruction. Arthritis Care Res (Hoboken). 2018 Aug;70(8):1132–1140.
Journal cover image

Published In

Arthritis Care Res (Hoboken)

DOI

EISSN

2151-4658

Publication Date

August 2018

Volume

70

Issue

8

Start / End Page

1132 / 1140

Location

United States

Related Subject Headings

  • Young Adult
  • Walking Speed
  • Treatment Outcome
  • Time Factors
  • Sex Factors
  • Recovery of Function
  • Male
  • Magnetic Resonance Imaging
  • Injury Severity Score
  • Imaging, Three-Dimensional