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Evaluating congenital syphilis in a reverse sequence testing environment.

Publication ,  Journal Article
Chen, MW; Akinboyo, IC; Sue, PK; Donohue, PK; Ghanem, KG; Detrick, B; Witter, FR; Page, KR; Arav-Boger, R; Golden, WC
Published in: J Perinatol
July 2019

OBJECTIVES: To examine the effect of maternal reverse-sequence (RS) syphilis screening on management of infants at risk for congenital syphilis (CS) using a standardized approach. STUDY DESIGN: A retrospective study from 2011 to 2014 at an academic medical center using RS testing, involving chemiluminescent immunoassay (CIA), rapid plasma  reagin (RPR), and fluorescent treponemal antibody-absorption (FTA-ABS) assays for syphilis. Clinical management and outcomes of infants born to mothers with discordant (CIA+/RPR-/FTA+) serology were compared with national or internal guidelines. RESULTS: Sixty-three infants were classified as discordant (n = 21), presumed false positive (CIA+/RPR-/FTA-; n = 16), or true positive (CIA+/RPR+; n = 26) based on maternal serology. Only 24% of cases in the discordant group underwent recommended full evaluation. None of the evaluated infants in the discordant group (n = 8) were diagnosed with CS. CONCLUSIONS: Management of infants with discordant maternal RS serology remained reliant on clinical judgment. In our high-risk population, RS testing did not identify additional cases of CS.

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Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

July 2019

Volume

39

Issue

7

Start / End Page

956 / 963

Location

United States

Related Subject Headings

  • Treponema pallidum
  • Syphilis, Congenital
  • Syphilis Serodiagnosis
  • Syphilis
  • Retrospective Studies
  • Pediatrics
  • Male
  • Luminescent Measurements
  • Infectious Disease Transmission, Vertical
  • Infant, Newborn
 

Citation

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Chen, M. W., Akinboyo, I. C., Sue, P. K., Donohue, P. K., Ghanem, K. G., Detrick, B., … Golden, W. C. (2019). Evaluating congenital syphilis in a reverse sequence testing environment. J Perinatol, 39(7), 956–963. https://doi.org/10.1038/s41372-019-0387-9
Chen, May W., Ibukunoluwa C. Akinboyo, Paul K. Sue, Pamela K. Donohue, Khalil G. Ghanem, Barbara Detrick, Frank R. Witter, Kathleen R. Page, Ravit Arav-Boger, and W Christopher Golden. “Evaluating congenital syphilis in a reverse sequence testing environment.J Perinatol 39, no. 7 (July 2019): 956–63. https://doi.org/10.1038/s41372-019-0387-9.
Chen MW, Akinboyo IC, Sue PK, Donohue PK, Ghanem KG, Detrick B, et al. Evaluating congenital syphilis in a reverse sequence testing environment. J Perinatol. 2019 Jul;39(7):956–63.
Chen, May W., et al. “Evaluating congenital syphilis in a reverse sequence testing environment.J Perinatol, vol. 39, no. 7, July 2019, pp. 956–63. Pubmed, doi:10.1038/s41372-019-0387-9.
Chen MW, Akinboyo IC, Sue PK, Donohue PK, Ghanem KG, Detrick B, Witter FR, Page KR, Arav-Boger R, Golden WC. Evaluating congenital syphilis in a reverse sequence testing environment. J Perinatol. 2019 Jul;39(7):956–963.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

July 2019

Volume

39

Issue

7

Start / End Page

956 / 963

Location

United States

Related Subject Headings

  • Treponema pallidum
  • Syphilis, Congenital
  • Syphilis Serodiagnosis
  • Syphilis
  • Retrospective Studies
  • Pediatrics
  • Male
  • Luminescent Measurements
  • Infectious Disease Transmission, Vertical
  • Infant, Newborn