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Discovery, Genomic Analysis, and Functional Role of the Erythrocyte RNAs

Publication ,  Journal Article
Chen, PH; Hong, J; Chi, JT
Published in: Current Pathobiology Reports
March 1, 2017

Purpose of Review: Human erythrocytes are responsible for oxygen delivery in the body. Erythrocytes are a product of terminal differentiated erythroid cells that accumulate hemoglobin and exclude nuclei. The long-held conventional wisdom has been that mature erythrocytes lack any genetic materials. Contrary to this view, accumulating evidence from multiple groups indicates that erythrocytes contain abundant and diverse RNA species. These newly discovered genetic materials suddenly open up opportunities to re-examine many diseases affecting erythrocytes. Recent Findings: The genomic analysis and functional studies of the erythrocyte transcriptome have revealed important insights into various erythrocyte diseases, stored erythrocytes for transfusion, host-pathogens interactions with malaria parasites, and intercellular communications. We reviewed these findings and provide conceptual frameworks for the future works on other potential applications of the erythrocyte transcriptome. Summary: Collectively, these studies provide a strong case for the translational potential and functional relevance of these erythrocyte transcripts.

Duke Scholars

Published In

Current Pathobiology Reports

DOI

EISSN

2167-485X

Publication Date

March 1, 2017

Volume

5

Issue

1

Start / End Page

43 / 48

Related Subject Headings

  • 3205 Medical biochemistry and metabolomics
  • 3202 Clinical sciences
  • 3101 Biochemistry and cell biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chen, P. H., Hong, J., & Chi, J. T. (2017). Discovery, Genomic Analysis, and Functional Role of the Erythrocyte RNAs. Current Pathobiology Reports, 5(1), 43–48. https://doi.org/10.1007/s40139-017-0124-z
Chen, P. H., J. Hong, and J. T. Chi. “Discovery, Genomic Analysis, and Functional Role of the Erythrocyte RNAs.” Current Pathobiology Reports 5, no. 1 (March 1, 2017): 43–48. https://doi.org/10.1007/s40139-017-0124-z.
Chen PH, Hong J, Chi JT. Discovery, Genomic Analysis, and Functional Role of the Erythrocyte RNAs. Current Pathobiology Reports. 2017 Mar 1;5(1):43–8.
Chen, P. H., et al. “Discovery, Genomic Analysis, and Functional Role of the Erythrocyte RNAs.” Current Pathobiology Reports, vol. 5, no. 1, Mar. 2017, pp. 43–48. Scopus, doi:10.1007/s40139-017-0124-z.
Chen PH, Hong J, Chi JT. Discovery, Genomic Analysis, and Functional Role of the Erythrocyte RNAs. Current Pathobiology Reports. 2017 Mar 1;5(1):43–48.
Journal cover image

Published In

Current Pathobiology Reports

DOI

EISSN

2167-485X

Publication Date

March 1, 2017

Volume

5

Issue

1

Start / End Page

43 / 48

Related Subject Headings

  • 3205 Medical biochemistry and metabolomics
  • 3202 Clinical sciences
  • 3101 Biochemistry and cell biology