Skip to main content
Journal cover image

A simple breathing circuit to maintain isocapnia during measurements of the hypoxic ventilatory response.

Publication ,  Journal Article
Fahlman, A; Jackson, S; Terblanche, J; Fisher, JA; Vesely, A; Sasano, H; Myburgh, KH
Published in: Respiratory physiology & neurobiology
November 2002

We report the development and testing of a simple breathing circuit that maintains isocapnia in human subjects during hypoxic hyperpnea. In addition, the circuit permits rapid switching between two gas mixtures with different partial pressures of oxygen. Eleven volunteers breathed repeated cycles of exposure to air (2 min of 21% O(2), balance N(2)) and hypoxia (2 min of 8.3+/-0.1% O(2), balance N(2)). Hypoxia induced significant increases in minute ventilation, breathing frequency and tidal volume (P < 0.05) that were consistent over repeated cycles of hypoxia (P > 0.1, one-way ANOVA). The system successfully maintained isocapnia in all subjects, with an average change in end-tidal CO(2) of only -0.2 mmHg during hyperventilation in hypoxia (range 0.4 to -0.8 mmHg). This system may be suitable for repeated tests of the hypoxic ventilatory response (HVR) and may prove useful for exploring intra- and inter-individual variability of HVR in humans.

Published In

Respiratory physiology & neurobiology

DOI

EISSN

1878-1519

ISSN

1569-9048

Publication Date

November 2002

Volume

133

Issue

3

Start / End Page

259 / 270

Related Subject Headings

  • Time Factors
  • Tidal Volume
  • Respiratory Mechanics
  • Respiration, Artificial
  • Respiration
  • Reference Values
  • Pulmonary Ventilation
  • Physiology
  • Partial Pressure
  • Oxygen
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fahlman, A., Jackson, S., Terblanche, J., Fisher, J. A., Vesely, A., Sasano, H., & Myburgh, K. H. (2002). A simple breathing circuit to maintain isocapnia during measurements of the hypoxic ventilatory response. Respiratory Physiology & Neurobiology, 133(3), 259–270. https://doi.org/10.1016/s1569-9048(02)00166-0
Fahlman, Andreas, Sue Jackson, John Terblanche, Joseph A. Fisher, Alex Vesely, Hiroshi Sasano, and Kathryn H. Myburgh. “A simple breathing circuit to maintain isocapnia during measurements of the hypoxic ventilatory response.Respiratory Physiology & Neurobiology 133, no. 3 (November 2002): 259–70. https://doi.org/10.1016/s1569-9048(02)00166-0.
Fahlman A, Jackson S, Terblanche J, Fisher JA, Vesely A, Sasano H, et al. A simple breathing circuit to maintain isocapnia during measurements of the hypoxic ventilatory response. Respiratory physiology & neurobiology. 2002 Nov;133(3):259–70.
Fahlman, Andreas, et al. “A simple breathing circuit to maintain isocapnia during measurements of the hypoxic ventilatory response.Respiratory Physiology & Neurobiology, vol. 133, no. 3, Nov. 2002, pp. 259–70. Epmc, doi:10.1016/s1569-9048(02)00166-0.
Fahlman A, Jackson S, Terblanche J, Fisher JA, Vesely A, Sasano H, Myburgh KH. A simple breathing circuit to maintain isocapnia during measurements of the hypoxic ventilatory response. Respiratory physiology & neurobiology. 2002 Nov;133(3):259–270.
Journal cover image

Published In

Respiratory physiology & neurobiology

DOI

EISSN

1878-1519

ISSN

1569-9048

Publication Date

November 2002

Volume

133

Issue

3

Start / End Page

259 / 270

Related Subject Headings

  • Time Factors
  • Tidal Volume
  • Respiratory Mechanics
  • Respiration, Artificial
  • Respiration
  • Reference Values
  • Pulmonary Ventilation
  • Physiology
  • Partial Pressure
  • Oxygen