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Role of Immune Response, Inflammation, and Tumor Immune Response-Related Cytokines/Chemokines in Melanoma Progression.

Publication ,  Journal Article
Fang, S; Xu, T; Xiong, M; Zhou, X; Wang, Y; Haydu, LE; Ross, MI; Gershenwald, JE; Prieto, VG; Cormier, JN; Wargo, J; Sui, D; Wei, Q; Amos, CI; Lee, JE
Published in: J Invest Dermatol
November 2019

To investigate the role of tumor cytokines/chemokines in melanoma immune response, we estimated the proportions of immune cell subsets in melanoma tumors from The Cancer Genome Atlas, followed by evaluation of the association between cytokine/chemokine expression and these subsets. We then investigated the association of immune cell subsets, chemokines, and cytokines with patient survival. Finally, we evaluated the immune cell tumor-infiltrating lymphocyte (TIL) score for correlation with melanoma patient outcome in a separate cohort. There was good agreement between RNA sequencing estimation of T-cell subset and pathologist-determined TIL score. Expression levels of cytokines IL-12A, IFNG, and IL-10, and chemokines CXCL9 and CXCL10 were positively correlated with PDCD1, CTLA-4, and CD8+ T-cell subset, but negatively correlated with tumor purity (Bonferroni-corrected P < 0.05). In multivariable analysis, higher expression levels of cytokines IFN-γ and TGFB1, but not chemokines, were associated with improved overall survival. A higher expression level of CD8+ T-cell subset was also associated with improved overall survival (hazard ratio [HR] = 0.06, 95% confidence interval [CI] = 0.01-0.35, P = 0.002). Finally, multivariable analysis showed that patients with a brisk TIL score had improved melanoma-specific survival than those with a nonbrisk score (HR = 0.51, 95% CI = 0.27-0.98, P = 0.0423). These results suggest that the expression of specific tumor cytokines represents important biomarkers of melanoma immune response.

Duke Scholars

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Published In

J Invest Dermatol

DOI

EISSN

1523-1747

Publication Date

November 2019

Volume

139

Issue

11

Start / End Page

2352 / 2358.e3

Location

United States

Related Subject Headings

  • Survival Analysis
  • Skin Neoplasms
  • Prognosis
  • Neoplasm Staging
  • Melanoma
  • Male
  • Lymphocytes, Tumor-Infiltrating
  • Inflammation
  • Immunity, Cellular
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fang, S., Xu, T., Xiong, M., Zhou, X., Wang, Y., Haydu, L. E., … Lee, J. E. (2019). Role of Immune Response, Inflammation, and Tumor Immune Response-Related Cytokines/Chemokines in Melanoma Progression. J Invest Dermatol, 139(11), 2352-2358.e3. https://doi.org/10.1016/j.jid.2019.03.1158
Fang, Shenying, Tao Xu, Momiao Xiong, Xinke Zhou, Yuling Wang, Lauren E. Haydu, Merrick I. Ross, et al. “Role of Immune Response, Inflammation, and Tumor Immune Response-Related Cytokines/Chemokines in Melanoma Progression.J Invest Dermatol 139, no. 11 (November 2019): 2352-2358.e3. https://doi.org/10.1016/j.jid.2019.03.1158.
Fang S, Xu T, Xiong M, Zhou X, Wang Y, Haydu LE, et al. Role of Immune Response, Inflammation, and Tumor Immune Response-Related Cytokines/Chemokines in Melanoma Progression. J Invest Dermatol. 2019 Nov;139(11):2352-2358.e3.
Fang, Shenying, et al. “Role of Immune Response, Inflammation, and Tumor Immune Response-Related Cytokines/Chemokines in Melanoma Progression.J Invest Dermatol, vol. 139, no. 11, Nov. 2019, pp. 2352-2358.e3. Pubmed, doi:10.1016/j.jid.2019.03.1158.
Fang S, Xu T, Xiong M, Zhou X, Wang Y, Haydu LE, Ross MI, Gershenwald JE, Prieto VG, Cormier JN, Wargo J, Sui D, Wei Q, Amos CI, Lee JE. Role of Immune Response, Inflammation, and Tumor Immune Response-Related Cytokines/Chemokines in Melanoma Progression. J Invest Dermatol. 2019 Nov;139(11):2352-2358.e3.

Published In

J Invest Dermatol

DOI

EISSN

1523-1747

Publication Date

November 2019

Volume

139

Issue

11

Start / End Page

2352 / 2358.e3

Location

United States

Related Subject Headings

  • Survival Analysis
  • Skin Neoplasms
  • Prognosis
  • Neoplasm Staging
  • Melanoma
  • Male
  • Lymphocytes, Tumor-Infiltrating
  • Inflammation
  • Immunity, Cellular
  • Humans