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Myocardial Na+/H+ exchanger-1 (NHE1) content is decreased by exercise training.

Publication ,  Journal Article
Feger, BJ; Starnes, JW
Published in: Journal of physiology and biochemistry
June 2013

The effect of exercise training on myocardial Na(+)/H(+) exchanger-1 (NHE1) protein expression was examined. Adult female Sprague-Dawley rats were randomly divided into sedentary (S; n = 8) and exercised (E; n = 9) groups. Twenty-four hours after the last exercise bout, hearts were weighed and connected to an isolated perfused working heart apparatus for evaluation of cardiac functional performance. Heart weight and heart weight/body weight from E rats was significantly increased by 7.1 and 7.2 % (P < 0.05), respectively, compared with S hearts. The E hearts displayed 15 % greater cardiac output and 35 % external cardiac work compared with the S group at both low and high workloads (P < 0.05 for both parameters). Left ventricular tissue from the same hearts was homogenized and NHE1 and Na(+)/Ca(2+) exchanger (NCX) content determined by Western blotting. E hearts had a 38 % (P < 0.001) reduction in NHE1 content related to S hearts, and there was no difference in NCX content between groups. Cytochrome c oxidase activity in plantaris increased by 100 % (P < 0.05) and was assessed as a marker of mitochondria content and to verify training status. Our data indicate that exercise training at an intensity that results in cardiac hypertrophy and improved performance is accompanied by decreased NHE1 content in heart.

Duke Scholars

Published In

Journal of physiology and biochemistry

DOI

EISSN

1877-8755

ISSN

1138-7548

Publication Date

June 2013

Volume

69

Issue

2

Start / End Page

305 / 312

Related Subject Headings

  • Sodium-Hydrogen Exchangers
  • Sodium-Hydrogen Exchanger 1
  • Sodium-Calcium Exchanger
  • Rats, Sprague-Dawley
  • Rats
  • Physical Conditioning, Animal
  • Myocardium
  • Female
  • Endocrinology & Metabolism
  • Electron Transport Complex IV
 

Citation

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Feger, B. J., & Starnes, J. W. (2013). Myocardial Na+/H+ exchanger-1 (NHE1) content is decreased by exercise training. Journal of Physiology and Biochemistry, 69(2), 305–312. https://doi.org/10.1007/s13105-012-0214-7
Feger, Bryan J., and Joseph W. Starnes. “Myocardial Na+/H+ exchanger-1 (NHE1) content is decreased by exercise training.Journal of Physiology and Biochemistry 69, no. 2 (June 2013): 305–12. https://doi.org/10.1007/s13105-012-0214-7.
Feger BJ, Starnes JW. Myocardial Na+/H+ exchanger-1 (NHE1) content is decreased by exercise training. Journal of physiology and biochemistry. 2013 Jun;69(2):305–12.
Feger, Bryan J., and Joseph W. Starnes. “Myocardial Na+/H+ exchanger-1 (NHE1) content is decreased by exercise training.Journal of Physiology and Biochemistry, vol. 69, no. 2, June 2013, pp. 305–12. Epmc, doi:10.1007/s13105-012-0214-7.
Feger BJ, Starnes JW. Myocardial Na+/H+ exchanger-1 (NHE1) content is decreased by exercise training. Journal of physiology and biochemistry. 2013 Jun;69(2):305–312.
Journal cover image

Published In

Journal of physiology and biochemistry

DOI

EISSN

1877-8755

ISSN

1138-7548

Publication Date

June 2013

Volume

69

Issue

2

Start / End Page

305 / 312

Related Subject Headings

  • Sodium-Hydrogen Exchangers
  • Sodium-Hydrogen Exchanger 1
  • Sodium-Calcium Exchanger
  • Rats, Sprague-Dawley
  • Rats
  • Physical Conditioning, Animal
  • Myocardium
  • Female
  • Endocrinology & Metabolism
  • Electron Transport Complex IV