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The side of the primary tumor affects overall survival in colon adenocarcinoma: an analysis of the national cancer database.

Publication ,  Journal Article
Turner, MC; Becerra, D; Sun, Z; Watson, J; Leung, K; Migaly, J; Mantyh, CR; Blazer, DG
Published in: Tech Coloproctol
June 2019

BACKGROUND: Due to conflicting study results on the effect of laterality on overall survival in primary colon cancers, we sought to examine the impact of left compared to right-sided primary tumors on overall survival for stage I-III colon cancer using the largest dataset to date. METHODS: The 2006-2013 NCDB was queried for patients with single primary, stage I-III colon adenocarcinoma and grouped by stage and tumor location. RESULTS: For stage I-II tumors, 114,839 patients had resection (62% right:38% left). After adjustment, patients with right-sided tumors had superior survival ([HR right as reference]: 1.13, 95% CI 1.09-1.17, p < 0.001). For stage III tumors, 71,024 patients had resection, (59% right:41% left). After adjustment, patients with left-sided tumors had superior survival with chemotherapy (HR 0.85, p < 0.001) and no difference in survival without chemotherapy (HR 0.97, p = 0.18). CONCLUSIONS: The side of the primary tumor impacts overall survival across stages for colon adenocarcinoma. Patients with right-sided tumors have superior survival for stage I-II disease while patients with left-sided stage III disease demonstrate a survival advantage, suggesting an opportunity for investigators to use sidedness as a surrogate for prognosis and chemoresponsiveness.

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Published In

Tech Coloproctol

DOI

EISSN

1128-045X

Publication Date

June 2019

Volume

23

Issue

6

Start / End Page

537 / 544

Location

Italy

Related Subject Headings

  • Survival Rate
  • Surgery
  • Prognosis
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Humans
  • Female
  • Databases, Factual
  • Colonic Neoplasms
 

Citation

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Turner, M. C., Becerra, D., Sun, Z., Watson, J., Leung, K., Migaly, J., … Blazer, D. G. (2019). The side of the primary tumor affects overall survival in colon adenocarcinoma: an analysis of the national cancer database. Tech Coloproctol, 23(6), 537–544. https://doi.org/10.1007/s10151-019-01997-w
Turner, M. C., D. Becerra, Z. Sun, J. Watson, K. Leung, J. Migaly, C. R. Mantyh, and D. G. Blazer. “The side of the primary tumor affects overall survival in colon adenocarcinoma: an analysis of the national cancer database.Tech Coloproctol 23, no. 6 (June 2019): 537–44. https://doi.org/10.1007/s10151-019-01997-w.
Turner MC, Becerra D, Sun Z, Watson J, Leung K, Migaly J, et al. The side of the primary tumor affects overall survival in colon adenocarcinoma: an analysis of the national cancer database. Tech Coloproctol. 2019 Jun;23(6):537–44.
Turner, M. C., et al. “The side of the primary tumor affects overall survival in colon adenocarcinoma: an analysis of the national cancer database.Tech Coloproctol, vol. 23, no. 6, June 2019, pp. 537–44. Pubmed, doi:10.1007/s10151-019-01997-w.
Turner MC, Becerra D, Sun Z, Watson J, Leung K, Migaly J, Mantyh CR, Blazer DG. The side of the primary tumor affects overall survival in colon adenocarcinoma: an analysis of the national cancer database. Tech Coloproctol. 2019 Jun;23(6):537–544.
Journal cover image

Published In

Tech Coloproctol

DOI

EISSN

1128-045X

Publication Date

June 2019

Volume

23

Issue

6

Start / End Page

537 / 544

Location

Italy

Related Subject Headings

  • Survival Rate
  • Surgery
  • Prognosis
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Humans
  • Female
  • Databases, Factual
  • Colonic Neoplasms