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Serum brain-derived neurotrophic factor concentrations in lean and overweight children and adolescents.

Publication ,  Journal Article
El-Gharbawy, AH; Adler-Wailes, DC; Mirch, MC; Theim, KR; Ranzenhofer, L; Tanofsky-Kraff, M; Yanovski, JA
Published in: J Clin Endocrinol Metab
September 2006

CONTEXT: Brain-derived neurotrophic factor (BDNF) and its receptor appear to be important components of the leptin-signaling cascade involved in energy homeostasis, and mice with BDNF or TrkB gene haploinsufficiency have excessive adiposity. Little is known about the relationship between adiposity and BDNF, particularly in children. OBJECTIVE: The objective of the study was to study the association of serum BDNF with measures of adiposity in children. DESIGN/SETTING/PATIENTS: BDNF was determined by a sandwich-type ELISA after an overnight fast in convenience sample of 328 subjects, aged 3-19 yr enriched for extreme obesity. In 43, BDNF was also measured before, and again 1 h after, consuming a high-energy content (787 kcal) milkshake. MAIN OUTCOME MEASURES: Measures included associations between BDNF and measures of adiposity. RESULTS: There were no significant univariate associations between log BDNF and adiposity measured by body mass index (BMI), BMI-Z score, or fat mass. However, in an analysis of covariance accounting for age, sex, race, pubertal status, and platelet count, BDNF was lower in overweight children (mean +/- sd, 39.8 +/- 24.8 vs. 47.0 +/- 25.4 ng/dl, P = 0.03); in multiple regression analyses with log BDNF as the dependent variable, BMI (P = 0.03), BMI-Z (P = 0.01), and body fat (P < 0.02) were all negatively associated with BDNF once age, pubertal status, and platelet count were included in the model. Ingestion of a meal did not significantly alter serum BDNF 1 h later (P = 0.26). CONCLUSIONS: Serum BDNF is lower in extremely overweight children and adolescents than those of normal weight. It remains to be determined whether obese individuals with low serum BDNF for age and platelet count have mutations that alter BDNF function.

Duke Scholars

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

September 2006

Volume

91

Issue

9

Start / End Page

3548 / 3552

Location

United States

Related Subject Headings

  • Plethysmography
  • Platelet Count
  • Overweight
  • Male
  • Linear Models
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Cohort Studies
  • Child, Preschool
 

Citation

APA
Chicago
ICMJE
MLA
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El-Gharbawy, A. H., Adler-Wailes, D. C., Mirch, M. C., Theim, K. R., Ranzenhofer, L., Tanofsky-Kraff, M., & Yanovski, J. A. (2006). Serum brain-derived neurotrophic factor concentrations in lean and overweight children and adolescents. J Clin Endocrinol Metab, 91(9), 3548–3552. https://doi.org/10.1210/jc.2006-0658
El-Gharbawy, Areeg H., Diane C. Adler-Wailes, Margaret C. Mirch, Kelly R. Theim, Lisa Ranzenhofer, Marian Tanofsky-Kraff, and Jack A. Yanovski. “Serum brain-derived neurotrophic factor concentrations in lean and overweight children and adolescents.J Clin Endocrinol Metab 91, no. 9 (September 2006): 3548–52. https://doi.org/10.1210/jc.2006-0658.
El-Gharbawy AH, Adler-Wailes DC, Mirch MC, Theim KR, Ranzenhofer L, Tanofsky-Kraff M, et al. Serum brain-derived neurotrophic factor concentrations in lean and overweight children and adolescents. J Clin Endocrinol Metab. 2006 Sep;91(9):3548–52.
El-Gharbawy, Areeg H., et al. “Serum brain-derived neurotrophic factor concentrations in lean and overweight children and adolescents.J Clin Endocrinol Metab, vol. 91, no. 9, Sept. 2006, pp. 3548–52. Pubmed, doi:10.1210/jc.2006-0658.
El-Gharbawy AH, Adler-Wailes DC, Mirch MC, Theim KR, Ranzenhofer L, Tanofsky-Kraff M, Yanovski JA. Serum brain-derived neurotrophic factor concentrations in lean and overweight children and adolescents. J Clin Endocrinol Metab. 2006 Sep;91(9):3548–3552.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

September 2006

Volume

91

Issue

9

Start / End Page

3548 / 3552

Location

United States

Related Subject Headings

  • Plethysmography
  • Platelet Count
  • Overweight
  • Male
  • Linear Models
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Cohort Studies
  • Child, Preschool