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Optimal efficient imaging time for identification of sentinel lymph node with Tc-99m Tilmanocept in breast cancer patients.

Publication ,  Conference
Baldeosingh, SC; Taylor-Cho, MW; Romano, LG; Knight Ii, JR; Borges-Neto Senior, S
Published in: Am J Nucl Med Mol Imaging
2020

We determined the optimal imaging time for axillary lymph node (LN) visualization following Tc-99m Tilmanocept in breast cancer patients to establish imaging guidelines that can allow for a reliable and efficient yet high yield study prior to surgery. Retrospective analysis in 651 patients who underwent lymphoscintigraphy, comparing LN visualization on immediate, 15-minute, and 90-minute delayed imaging after injection of Tc-99m Tilmanocept. Statistical analysis was performed using McNemar's test, kappa coefficient, and Pearson Chi-square test. Five hundred and six patients had either immediate or immediate and 90-minute delayed imaging. Of these patients, 203 (40.1%) had both immediate and 90-minute delayed images. Of these 203 patients, 54 (26.6%) had ≥1 lymph node(s) identified immediately and 196 (96.6%) had ≥1 lymph node(s) identified at 90 minutes (P<0.0001). A kappa coefficient of .0256 was observed (95% CI: .0058-.0453). One hundred and forty-five additional patients had 15-minute delayed imaging. Of these patients, 117 (80.7%) had ≥1 lymph node(s) identified, which was significantly fewer compared to the number of patients with ≥1 lymph node(s) detected at 90 minutes (P<0.0001). Ninety-minute delayed imaging is optimal for identifying sentinel lymph node(s) following Tc-99m Tilmanocept injection in breast cancer patients.

Duke Scholars

Published In

Am J Nucl Med Mol Imaging

ISSN

2160-8407

Publication Date

2020

Volume

10

Issue

5

Start / End Page

243 / 248

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Baldeosingh, S. C., Taylor-Cho, M. W., Romano, L. G., Knight Ii, J. R., & Borges-Neto Senior, S. (2020). Optimal efficient imaging time for identification of sentinel lymph node with Tc-99m Tilmanocept in breast cancer patients. In Am J Nucl Med Mol Imaging (Vol. 10, pp. 243–248). United States.
Baldeosingh, Sacha C., Michael W. Taylor-Cho, Linda G. Romano, John R. Knight Ii, and Salvador Borges-Neto Senior. “Optimal efficient imaging time for identification of sentinel lymph node with Tc-99m Tilmanocept in breast cancer patients.” In Am J Nucl Med Mol Imaging, 10:243–48, 2020.
Baldeosingh SC, Taylor-Cho MW, Romano LG, Knight Ii JR, Borges-Neto Senior S. Optimal efficient imaging time for identification of sentinel lymph node with Tc-99m Tilmanocept in breast cancer patients. In: Am J Nucl Med Mol Imaging. 2020. p. 243–8.
Baldeosingh, Sacha C., et al. “Optimal efficient imaging time for identification of sentinel lymph node with Tc-99m Tilmanocept in breast cancer patients.Am J Nucl Med Mol Imaging, vol. 10, no. 5, 2020, pp. 243–48.
Baldeosingh SC, Taylor-Cho MW, Romano LG, Knight Ii JR, Borges-Neto Senior S. Optimal efficient imaging time for identification of sentinel lymph node with Tc-99m Tilmanocept in breast cancer patients. Am J Nucl Med Mol Imaging. 2020. p. 243–248.

Published In

Am J Nucl Med Mol Imaging

ISSN

2160-8407

Publication Date

2020

Volume

10

Issue

5

Start / End Page

243 / 248

Location

United States