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Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites.

Publication ,  Journal Article
Menon, V; Musial, TF; Liu, A; Katz, Y; Kath, WL; Spruston, N; Nicholson, DA
Published in: Neuron
December 2013

Neuronal computation involves the integration of synaptic inputs that are often distributed over expansive dendritic trees, suggesting the need for compensatory mechanisms that enable spatially disparate synapses to influence neuronal output. In hippocampal CA1 pyramidal neurons, such mechanisms have indeed been reported, which normalize either the ability of distributed synapses to drive action potential initiation in the axon or their ability to drive dendritic spiking locally. Here we report that these mechanisms can coexist, through an elegant combination of distance-dependent regulation of synapse number and synaptic expression of AMPA and NMDA receptors. Together, these complementary gradients allow individual dendrites in both the apical and basal dendritic trees of hippocampal neurons to operate as facile computational subunits capable of supporting both global integration in the soma/axon and local integration in the dendrite.

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Published In

Neuron

DOI

EISSN

1097-4199

ISSN

0896-6273

Publication Date

December 2013

Volume

80

Issue

6

Start / End Page

1451 / 1463

Related Subject Headings

  • Synapses
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, AMPA
  • Rats
  • Pyramidal Cells
  • Neurology & Neurosurgery
  • Models, Neurological
  • Membrane Potentials
  • Male
  • Excitatory Postsynaptic Potentials
 

Citation

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Menon, V., Musial, T. F., Liu, A., Katz, Y., Kath, W. L., Spruston, N., & Nicholson, D. A. (2013). Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites. Neuron, 80(6), 1451–1463. https://doi.org/10.1016/j.neuron.2013.09.027
Menon, Vilas, Timothy F. Musial, Annie Liu, Yael Katz, William L. Kath, Nelson Spruston, and Daniel A. Nicholson. “Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites.Neuron 80, no. 6 (December 2013): 1451–63. https://doi.org/10.1016/j.neuron.2013.09.027.
Menon V, Musial TF, Liu A, Katz Y, Kath WL, Spruston N, et al. Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites. Neuron. 2013 Dec;80(6):1451–63.
Menon, Vilas, et al. “Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites.Neuron, vol. 80, no. 6, Dec. 2013, pp. 1451–63. Epmc, doi:10.1016/j.neuron.2013.09.027.
Menon V, Musial TF, Liu A, Katz Y, Kath WL, Spruston N, Nicholson DA. Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites. Neuron. 2013 Dec;80(6):1451–1463.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

ISSN

0896-6273

Publication Date

December 2013

Volume

80

Issue

6

Start / End Page

1451 / 1463

Related Subject Headings

  • Synapses
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, AMPA
  • Rats
  • Pyramidal Cells
  • Neurology & Neurosurgery
  • Models, Neurological
  • Membrane Potentials
  • Male
  • Excitatory Postsynaptic Potentials