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Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T.

Publication ,  Journal Article
Sitek, KR; Gulban, OF; Calabrese, E; Johnson, GA; Lage-Castellanos, A; Moerel, M; Ghosh, SS; De Martino, F
Published in: Elife
August 1, 2019

Studying the human subcortical auditory system non-invasively is challenging due to its small, densely packed structures deep within the brain. Additionally, the elaborate three-dimensional (3-D) structure of the system can be difficult to understand based on currently available 2-D schematics and animal models. Wfe addressed these issues using a combination of histological data, post mortem magnetic resonance imaging (MRI), and in vivo MRI at 7 Tesla. We created anatomical atlases based on state-of-the-art human histology (BigBrain) and postmortem MRI (50 µm). We measured functional MRI (fMRI) responses to natural sounds and demonstrate that the functional localization of subcortical structures is reliable within individual participants who were scanned in two different experiments. Further, a group functional atlas derived from the functional data locates these structures with a median distance below 2 mm. Using diffusion MRI tractography, we revealed structural connectivity maps of the human subcortical auditory pathway both in vivo (1050 µm isotropic resolution) and post mortem (200 µm isotropic resolution). This work captures current MRI capabilities for investigating the human subcortical auditory system, describes challenges that remain, and contributes novel, openly available data, atlases, and tools for researching the human auditory system.

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Published In

Elife

DOI

EISSN

2050-084X

Publication Date

August 1, 2019

Volume

8

Location

England

Related Subject Headings

  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Histocytochemistry
  • Female
  • Brain Mapping
  • Auditory Pathways
  • Adult
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

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Sitek, K. R., Gulban, O. F., Calabrese, E., Johnson, G. A., Lage-Castellanos, A., Moerel, M., … De Martino, F. (2019). Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T. Elife, 8. https://doi.org/10.7554/eLife.48932
Sitek, Kevin R., Omer Faruk Gulban, Evan Calabrese, G Allan Johnson, Agustin Lage-Castellanos, Michelle Moerel, Satrajit S. Ghosh, and Federico De Martino. “Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T.Elife 8 (August 1, 2019). https://doi.org/10.7554/eLife.48932.
Sitek KR, Gulban OF, Calabrese E, Johnson GA, Lage-Castellanos A, Moerel M, et al. Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T. Elife. 2019 Aug 1;8.
Sitek, Kevin R., et al. “Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T.Elife, vol. 8, Aug. 2019. Pubmed, doi:10.7554/eLife.48932.
Sitek KR, Gulban OF, Calabrese E, Johnson GA, Lage-Castellanos A, Moerel M, Ghosh SS, De Martino F. Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T. Elife. 2019 Aug 1;8.

Published In

Elife

DOI

EISSN

2050-084X

Publication Date

August 1, 2019

Volume

8

Location

England

Related Subject Headings

  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Histocytochemistry
  • Female
  • Brain Mapping
  • Auditory Pathways
  • Adult
  • 42 Health sciences
  • 32 Biomedical and clinical sciences