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Thrombomodulin in disseminated intravascular coagulation and other critical conditions-a multi-faceted anticoagulant protein with therapeutic potential.

Publication ,  Journal Article
Ito, T; Thachil, J; Asakura, H; Levy, JH; Iba, T
Published in: Crit Care
August 15, 2019

Thrombomodulin plays a vital role in maintaining intravascular patency due to its anticoagulant, antiinflammatory, and cytoprotective properties. However, under pathological conditions such as sepsis and systemic inflammation, endothelial thrombomodulin expression is downregulated and its function impaired. As a result, administering thrombomodulin represents a potential therapeutic modality. Recently, the effect of recombinant thrombomodulin administration in sepsis-induced coagulopathy was evaluated in a randomized controlled study (SCARLET). A 2.6% 28-day absolute mortality reduction (26.8% vs. 29.4%) was reported in 800 patients studied that was not statistically significant; however, a post hoc analysis revealed a 5.4% absolute mortality reduction among the patients who fulfilled the entry criterion at baseline. The risk of bleeding did not increase compared to placebo control. Favorable effects of thrombomodulin administration have been reported not only in sepsis-induced coagulopathy but also in disseminated intravascular coagulations with various backgrounds. Interestingly, beneficial effects of recombinant thrombomodulin in respiratory, renal, and cardiovascular diseases might depend on its anti-inflammatory mechanisms. In this review, we summarize the accumulated knowledge of endogenous as well as recombinant thrombomodulin from basic to clinical aspects and suggest future directions for this novel therapeutic agent.

Duke Scholars

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Published In

Crit Care

DOI

EISSN

1466-609X

Publication Date

August 15, 2019

Volume

23

Issue

1

Start / End Page

280

Location

England

Related Subject Headings

  • Thrombomodulin
  • Sepsis
  • Recombinant Proteins
  • Humans
  • Emergency & Critical Care Medicine
  • Disseminated Intravascular Coagulation
  • Anticoagulants
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences
 

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Ito, T., Thachil, J., Asakura, H., Levy, J. H., & Iba, T. (2019). Thrombomodulin in disseminated intravascular coagulation and other critical conditions-a multi-faceted anticoagulant protein with therapeutic potential. Crit Care, 23(1), 280. https://doi.org/10.1186/s13054-019-2552-0
Ito, Takashi, Jecko Thachil, Hidesaku Asakura, Jerrold H. Levy, and Toshiaki Iba. “Thrombomodulin in disseminated intravascular coagulation and other critical conditions-a multi-faceted anticoagulant protein with therapeutic potential.Crit Care 23, no. 1 (August 15, 2019): 280. https://doi.org/10.1186/s13054-019-2552-0.
Ito, Takashi, et al. “Thrombomodulin in disseminated intravascular coagulation and other critical conditions-a multi-faceted anticoagulant protein with therapeutic potential.Crit Care, vol. 23, no. 1, Aug. 2019, p. 280. Pubmed, doi:10.1186/s13054-019-2552-0.

Published In

Crit Care

DOI

EISSN

1466-609X

Publication Date

August 15, 2019

Volume

23

Issue

1

Start / End Page

280

Location

England

Related Subject Headings

  • Thrombomodulin
  • Sepsis
  • Recombinant Proteins
  • Humans
  • Emergency & Critical Care Medicine
  • Disseminated Intravascular Coagulation
  • Anticoagulants
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences