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Cholesterol and cognitive performance among community volunteers from the Czech Republic.

Publication ,  Journal Article
Chanti-Ketterl, M; Andel, R; Lerch, O; Laczo, J; Hort, J
Published in: Int Psychogeriatr
December 2015

BACKGROUND: Research shows that lipid levels may be associated with cognitive function, particularly among women. We aimed to examine total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein (HDL), and HDL/LDL ratio in relation to cognitive performance, measured with six well-established cognitive domains and a composite cognitive score (CCS). METHODS: In this cross-sectional study, biomarkers and neuropsychological assessment were available for 141 adults with MMSE scores ≥ 24 (mean age = 69 years, 47% female, mean education = 14.4 years) attending a neuropsychological evaluation. Ordinary least squares regressions were adjusted for age, gender, education, and depressive symptoms in Model 1 and also for apolipoprotein E4 (APOE4) status in Model 2. RESULTS: High-density lipoprotein cholesterol (HDL-C) was associated with better CCS (β = 0.24; p = 0.014). This association was significant among women (β = 0.30; p = 0.026) and not among men (β = 0.20; p = 0.124). HDL-C was also related to attention/working memory (β = 0.24; p = 0.021), again only among women (β = 0.37; p = 0.012) and not men (β = 0.15; p = 0.271). Adjusting for APOE4 yielded significance for high HDL-C and CCS (β = 0.24; p = 0.022). CONCLUSIONS: HDL-C was the main lipoprotein affecting cognitive function, with results somewhat more pronounced among women. Research should investigate the possibility of finding ways to boost HDL-C levels to potentially promote cognitive function.

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Published In

Int Psychogeriatr

DOI

EISSN

1741-203X

Publication Date

December 2015

Volume

27

Issue

12

Start / End Page

2087 / 2095

Location

England

Related Subject Headings

  • Volunteers
  • Triglycerides
  • Regression Analysis
  • Psychiatric Status Rating Scales
  • Neuropsychological Tests
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Humans
  • Geriatrics
 

Citation

APA
Chicago
ICMJE
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Chanti-Ketterl, M., Andel, R., Lerch, O., Laczo, J., & Hort, J. (2015). Cholesterol and cognitive performance among community volunteers from the Czech Republic. Int Psychogeriatr, 27(12), 2087–2095. https://doi.org/10.1017/S1041610215000320
Chanti-Ketterl, Marianne, Ross Andel, Ondrej Lerch, Jan Laczo, and Jakub Hort. “Cholesterol and cognitive performance among community volunteers from the Czech Republic.Int Psychogeriatr 27, no. 12 (December 2015): 2087–95. https://doi.org/10.1017/S1041610215000320.
Chanti-Ketterl M, Andel R, Lerch O, Laczo J, Hort J. Cholesterol and cognitive performance among community volunteers from the Czech Republic. Int Psychogeriatr. 2015 Dec;27(12):2087–95.
Chanti-Ketterl, Marianne, et al. “Cholesterol and cognitive performance among community volunteers from the Czech Republic.Int Psychogeriatr, vol. 27, no. 12, Dec. 2015, pp. 2087–95. Pubmed, doi:10.1017/S1041610215000320.
Chanti-Ketterl M, Andel R, Lerch O, Laczo J, Hort J. Cholesterol and cognitive performance among community volunteers from the Czech Republic. Int Psychogeriatr. 2015 Dec;27(12):2087–2095.
Journal cover image

Published In

Int Psychogeriatr

DOI

EISSN

1741-203X

Publication Date

December 2015

Volume

27

Issue

12

Start / End Page

2087 / 2095

Location

England

Related Subject Headings

  • Volunteers
  • Triglycerides
  • Regression Analysis
  • Psychiatric Status Rating Scales
  • Neuropsychological Tests
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Humans
  • Geriatrics