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Role of transcription factor NFAT in glucose and insulin homeostasis.

Publication ,  Journal Article
Yang, TTC; Suk, HY; Yang, X; Olabisi, O; Yu, RYL; Durand, J; Jelicks, LA; Kim, J-Y; Scherer, PE; Wang, Y; Feng, Y; Rossetti, L; Graef, IA ...
Published in: Mol Cell Biol
October 2006

Compromised immunoregulation contributes to obesity and complications in metabolic pathogenesis. Here, we demonstrate that the nuclear factor of activated T cell (NFAT) group of transcription factors contributes to glucose and insulin homeostasis. Expression of two members of the NFAT family (NFATc2 and NFATc4) is induced upon adipogenesis and in obese mice. Mice with the Nfatc2-/- Nfatc4-/- compound disruption exhibit defects in fat accumulation and are lean. Nfatc2-/- Nfatc4-/- mice are also protected from diet-induced obesity. Ablation of NFATc2 and NFATc4 increases insulin sensitivity, in part, by sustained activation of the insulin signaling pathway. Nfatc2-/- Nfatc4-/- mice also exhibit an altered adipokine profile, with reduced resistin and leptin levels. Mechanistically, NFAT is recruited to the transcription loci and regulates resistin gene expression upon insulin stimulation. Together, these results establish a role for NFAT in glucose/insulin homeostasis and expand the repertoire of NFAT function to metabolic pathogenesis and adipokine gene transcription.

Duke Scholars

Published In

Mol Cell Biol

DOI

ISSN

0270-7306

Publication Date

October 2006

Volume

26

Issue

20

Start / End Page

7372 / 7387

Location

United States

Related Subject Headings

  • Signal Transduction
  • Sensitivity and Specificity
  • Resistin
  • Protein Serine-Threonine Kinases
  • Obesity
  • NFATC Transcription Factors
  • Multienzyme Complexes
  • Mice, Knockout
  • Mice
  • Insulin
 

Citation

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Yang, T. T. C., Suk, H. Y., Yang, X., Olabisi, O., Yu, R. Y. L., Durand, J., … Chow, C.-W. (2006). Role of transcription factor NFAT in glucose and insulin homeostasis. Mol Cell Biol, 26(20), 7372–7387. https://doi.org/10.1128/MCB.00580-06
Yang, Teddy T. C., Hee Yun Suk, Xiaoyong Yang, Opeyemi Olabisi, Raymond Y. L. Yu, Jorge Durand, Linda A. Jelicks, et al. “Role of transcription factor NFAT in glucose and insulin homeostasis.Mol Cell Biol 26, no. 20 (October 2006): 7372–87. https://doi.org/10.1128/MCB.00580-06.
Yang TTC, Suk HY, Yang X, Olabisi O, Yu RYL, Durand J, et al. Role of transcription factor NFAT in glucose and insulin homeostasis. Mol Cell Biol. 2006 Oct;26(20):7372–87.
Yang, Teddy T. C., et al. “Role of transcription factor NFAT in glucose and insulin homeostasis.Mol Cell Biol, vol. 26, no. 20, Oct. 2006, pp. 7372–87. Pubmed, doi:10.1128/MCB.00580-06.
Yang TTC, Suk HY, Yang X, Olabisi O, Yu RYL, Durand J, Jelicks LA, Kim J-Y, Scherer PE, Wang Y, Feng Y, Rossetti L, Graef IA, Crabtree GR, Chow C-W. Role of transcription factor NFAT in glucose and insulin homeostasis. Mol Cell Biol. 2006 Oct;26(20):7372–7387.

Published In

Mol Cell Biol

DOI

ISSN

0270-7306

Publication Date

October 2006

Volume

26

Issue

20

Start / End Page

7372 / 7387

Location

United States

Related Subject Headings

  • Signal Transduction
  • Sensitivity and Specificity
  • Resistin
  • Protein Serine-Threonine Kinases
  • Obesity
  • NFATC Transcription Factors
  • Multienzyme Complexes
  • Mice, Knockout
  • Mice
  • Insulin