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Oncogenic and metastatic properties of preprotachykinin-I and neurokinin-1 genes.

Publication ,  Journal Article
Singh, AS; Caplan, A; Corcoran, KE; Fernandez, JS; Preziosi, M; Rameshwar, P
Published in: Vascul Pharmacol
October 2006

Breast cancer (BC) remains the cancer with highest mortality among women in the United States. Entry of BC cells (BCCs) in bone marrow (BM) leads to poor prognosis. This review discusses studies showing interactions between BCCs and BM stroma, consequently providing BCCs with advantages of survival within BM. Myc transcription factor is investigated as a link between the transforming properties of peptides derived from the preprotachykinin-I gene (PPT-I) and Neurokinin-1 (NK1) receptor. A co-culture method previously described to model early integration of BCC in BM is used to study timeline changes of PPT-I and TGF-beta using northern analyses and a bioassay, respectively. The results show changes of both genes in BCCs and BM stroma. Relevance of these changes to homeostasis in BM is discussed. Myc has been shown to link the expressions of TGF-beta1 and PPT-I in BCCs. We now show a role for Myc in the expression of NK1. PPT-I and the chemokine SDF-1alpha induce the expression of each other through an autocrine mechanism. Since a role for Myc in SDF-1alpha-PPT-I axis has not been studied, we speculate on this finding, based on the cell-homing property of SDF-1alpha. Since Myc could be oncogenic, it might be involved in the transforming properties of PPT-I and NK1 while SDF-1alpha could be involved in cell-homing of BCCs through the regulation of PPT-I. The findings are discussed in the context of other related reports.

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Published In

Vascul Pharmacol

DOI

ISSN

1537-1891

Publication Date

October 2006

Volume

45

Issue

4

Start / End Page

235 / 242

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta1
  • Transfection
  • Tachykinins
  • Review Literature as Topic
  • Receptors, Neurokinin-1
  • Proto-Oncogene Proteins c-myc
  • Protein Precursors
  • Neoplasm Metastasis
  • Models, Biological
  • Humans
 

Citation

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Singh, A. S., Caplan, A., Corcoran, K. E., Fernandez, J. S., Preziosi, M., & Rameshwar, P. (2006). Oncogenic and metastatic properties of preprotachykinin-I and neurokinin-1 genes. Vascul Pharmacol, 45(4), 235–242. https://doi.org/10.1016/j.vph.2005.08.029
Singh, Arun S., Andrew Caplan, Kelly E. Corcoran, Joseph S. Fernandez, Michael Preziosi, and Pranela Rameshwar. “Oncogenic and metastatic properties of preprotachykinin-I and neurokinin-1 genes.Vascul Pharmacol 45, no. 4 (October 2006): 235–42. https://doi.org/10.1016/j.vph.2005.08.029.
Singh AS, Caplan A, Corcoran KE, Fernandez JS, Preziosi M, Rameshwar P. Oncogenic and metastatic properties of preprotachykinin-I and neurokinin-1 genes. Vascul Pharmacol. 2006 Oct;45(4):235–42.
Singh, Arun S., et al. “Oncogenic and metastatic properties of preprotachykinin-I and neurokinin-1 genes.Vascul Pharmacol, vol. 45, no. 4, Oct. 2006, pp. 235–42. Pubmed, doi:10.1016/j.vph.2005.08.029.
Singh AS, Caplan A, Corcoran KE, Fernandez JS, Preziosi M, Rameshwar P. Oncogenic and metastatic properties of preprotachykinin-I and neurokinin-1 genes. Vascul Pharmacol. 2006 Oct;45(4):235–242.
Journal cover image

Published In

Vascul Pharmacol

DOI

ISSN

1537-1891

Publication Date

October 2006

Volume

45

Issue

4

Start / End Page

235 / 242

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta1
  • Transfection
  • Tachykinins
  • Review Literature as Topic
  • Receptors, Neurokinin-1
  • Proto-Oncogene Proteins c-myc
  • Protein Precursors
  • Neoplasm Metastasis
  • Models, Biological
  • Humans