Simultaneous estimation of paracetamol and promethazine hydrochloride in pharmaceutical formulations by a RP-HPLC method
Publication
, Journal Article
Borkar, DD; Godse, VP; Bafana, YS; Bhosale, AV
Published in: International Journal of Chemtech Research
December 1, 2009
A rapid and sensitive high performance liquid chromatography method for determination of paracetamol and promethazine hydrochloride has been developed. The chromatography system used a reversed phase C18 column (HiQ Sil C18, 5μ, 250 mm x 4.6 mm). The sample was analyzed using Methanol: Water: Try ethyl amine, in the ratio of 90:10:0.1 v/v as a mobile phase at a flow rate of 1.0 ml/min and detection at 250 nm. The retention time for paracetamol and promethazine hydrochloride was found to be 2.853 and 5.107 min respectively, and recoveries from formulation were between 98 and 102 %. The method can be used for estimation of combination of these drugs formulations.
Duke Scholars
Published In
International Journal of Chemtech Research
EISSN
0974-4290
Publication Date
December 1, 2009
Volume
1
Issue
3
Start / End Page
667 / 670
Citation
APA
Chicago
ICMJE
MLA
NLM
Borkar, D. D., Godse, V. P., Bafana, Y. S., & Bhosale, A. V. (2009). Simultaneous estimation of paracetamol and promethazine hydrochloride in pharmaceutical formulations by a RP-HPLC method. International Journal of Chemtech Research, 1(3), 667–670.
Borkar, D. D., V. P. Godse, Y. S. Bafana, and A. V. Bhosale. “Simultaneous estimation of paracetamol and promethazine hydrochloride in pharmaceutical formulations by a RP-HPLC method.” International Journal of Chemtech Research 1, no. 3 (December 1, 2009): 667–70.
Borkar DD, Godse VP, Bafana YS, Bhosale AV. Simultaneous estimation of paracetamol and promethazine hydrochloride in pharmaceutical formulations by a RP-HPLC method. International Journal of Chemtech Research. 2009 Dec 1;1(3):667–70.
Borkar, D. D., et al. “Simultaneous estimation of paracetamol and promethazine hydrochloride in pharmaceutical formulations by a RP-HPLC method.” International Journal of Chemtech Research, vol. 1, no. 3, Dec. 2009, pp. 667–70.
Borkar DD, Godse VP, Bafana YS, Bhosale AV. Simultaneous estimation of paracetamol and promethazine hydrochloride in pharmaceutical formulations by a RP-HPLC method. International Journal of Chemtech Research. 2009 Dec 1;1(3):667–670.
Published In
International Journal of Chemtech Research
EISSN
0974-4290
Publication Date
December 1, 2009
Volume
1
Issue
3
Start / End Page
667 / 670