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Application of stem cell transplantation in autoimmune diseases.

Publication ,  Journal Article
Ng, S-A; Sullivan, KM
Published in: Curr Opin Hematol
November 2019

PURPOSE OF REVIEW: Autologous hematopoietic stem cell transplantation (HSCT) is a promising therapeutic modality for severe autoimmune diseases. In this review, we will outline the immunological mechanisms and the clinical evidence and experiences for therapeutic HSCT in autoimmune diseases, with particular focus on systemic sclerosis and multiple sclerosis. RECENT FINDINGS: Approximately 3000 patients with autoimmune diseases worldwide have been treated with HSCT. HSCT in systemic sclerosis has been shown in three randomized controlled trials to be associated with significant long-term event-free survival despite some transplant-related mortality in the first year. A recent controlled trial in multiple sclerosis has also show benefit with transplant. SUMMARY: The aim of HSCT is to 'reset' one's immune system into a naïve and self-tolerant state through immune depletion and regulation. HSCT requires careful patient selection, close collaboration between physicians and expertise of transplant team to ensure optimal outcome.

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Published In

Curr Opin Hematol

DOI

EISSN

1531-7048

Publication Date

November 2019

Volume

26

Issue

6

Start / End Page

392 / 398

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Recurrence
  • Multiple Sclerosis
  • Immunology
  • Immunocompromised Host
  • Immune Tolerance
  • Immune Reconstitution
  • Humans
  • Hematopoietic Stem Cell Transplantation
 

Citation

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Ng, S.-A., & Sullivan, K. M. (2019). Application of stem cell transplantation in autoimmune diseases. Curr Opin Hematol, 26(6), 392–398. https://doi.org/10.1097/MOH.0000000000000531
Ng, Sue-Ann, and Keith M. Sullivan. “Application of stem cell transplantation in autoimmune diseases.Curr Opin Hematol 26, no. 6 (November 2019): 392–98. https://doi.org/10.1097/MOH.0000000000000531.
Ng S-A, Sullivan KM. Application of stem cell transplantation in autoimmune diseases. Curr Opin Hematol. 2019 Nov;26(6):392–8.
Ng, Sue-Ann, and Keith M. Sullivan. “Application of stem cell transplantation in autoimmune diseases.Curr Opin Hematol, vol. 26, no. 6, Nov. 2019, pp. 392–98. Pubmed, doi:10.1097/MOH.0000000000000531.
Ng S-A, Sullivan KM. Application of stem cell transplantation in autoimmune diseases. Curr Opin Hematol. 2019 Nov;26(6):392–398.

Published In

Curr Opin Hematol

DOI

EISSN

1531-7048

Publication Date

November 2019

Volume

26

Issue

6

Start / End Page

392 / 398

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Recurrence
  • Multiple Sclerosis
  • Immunology
  • Immunocompromised Host
  • Immune Tolerance
  • Immune Reconstitution
  • Humans
  • Hematopoietic Stem Cell Transplantation