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Methionine metabolism in health and cancer: a nexus of diet and precision medicine.

Publication ,  Journal Article
Sanderson, SM; Gao, X; Dai, Z; Locasale, JW
Published in: Nat Rev Cancer
November 2019

Methionine uptake and metabolism is involved in a host of cellular functions including methylation reactions, redox maintenance, polyamine synthesis and coupling to folate metabolism, thus coordinating nucleotide and redox status. Each of these functions has been shown in many contexts to be relevant for cancer pathogenesis. Intriguingly, the levels of methionine obtained from the diet can have a large effect on cellular methionine metabolism. This establishes a link between nutrition and tumour cell metabolism that may allow for tumour-specific metabolic vulnerabilities that can be influenced by diet. Recently, a number of studies have begun to investigate the molecular and cellular mechanisms that underlie the interaction between nutrition, methionine metabolism and effects on health and cancer.

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Published In

Nat Rev Cancer

DOI

EISSN

1474-1768

Publication Date

November 2019

Volume

19

Issue

11

Start / End Page

625 / 637

Location

England

Related Subject Headings

  • RNA
  • Precision Medicine
  • Polyamines
  • Oxidation-Reduction
  • Oncology & Carcinogenesis
  • Nutritional Sciences
  • Neoplasms
  • Methionine
  • Humans
  • Histones
 

Citation

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Sanderson, S. M., Gao, X., Dai, Z., & Locasale, J. W. (2019). Methionine metabolism in health and cancer: a nexus of diet and precision medicine. Nat Rev Cancer, 19(11), 625–637. https://doi.org/10.1038/s41568-019-0187-8
Sanderson, Sydney M., Xia Gao, Ziwei Dai, and Jason W. Locasale. “Methionine metabolism in health and cancer: a nexus of diet and precision medicine.Nat Rev Cancer 19, no. 11 (November 2019): 625–37. https://doi.org/10.1038/s41568-019-0187-8.
Sanderson SM, Gao X, Dai Z, Locasale JW. Methionine metabolism in health and cancer: a nexus of diet and precision medicine. Nat Rev Cancer. 2019 Nov;19(11):625–37.
Sanderson, Sydney M., et al. “Methionine metabolism in health and cancer: a nexus of diet and precision medicine.Nat Rev Cancer, vol. 19, no. 11, Nov. 2019, pp. 625–37. Pubmed, doi:10.1038/s41568-019-0187-8.
Sanderson SM, Gao X, Dai Z, Locasale JW. Methionine metabolism in health and cancer: a nexus of diet and precision medicine. Nat Rev Cancer. 2019 Nov;19(11):625–637.

Published In

Nat Rev Cancer

DOI

EISSN

1474-1768

Publication Date

November 2019

Volume

19

Issue

11

Start / End Page

625 / 637

Location

England

Related Subject Headings

  • RNA
  • Precision Medicine
  • Polyamines
  • Oxidation-Reduction
  • Oncology & Carcinogenesis
  • Nutritional Sciences
  • Neoplasms
  • Methionine
  • Humans
  • Histones