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The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis of Cryptococcus Human Pathogenic Fungi.

Publication ,  Journal Article
Sun, S; Coelho, MA; David-Palma, M; Priest, SJ; Heitman, J
Published in: Annu Rev Genet
December 3, 2019

Cryptococcus species utilize a variety of sexual reproduction mechanisms, which generate genetic diversity, purge deleterious mutations, and contribute to their ability to occupy myriad environmental niches and exhibit a range of pathogenic potential. The bisexual and unisexual cycles of pathogenic Cryptococcus species are stimulated by properties associated with their environmental niches and proceed through well-characterized signaling pathways and corresponding morphological changes. Genes governing mating are encoded by the mating-type (MAT) loci and influence pathogenesis, population dynamics, and lineage divergence in Cryptococcus. MAT has undergone significant evolutionary changes within the Cryptococcus genus, including transition from the ancestral tetrapolar state in nonpathogenic species to a bipolar mating system in pathogenic species, as well as several internal reconfigurations. Owing to the variety of established sexual reproduction mechanisms and the robust characterization of the evolution of mating and MAT in this genus, Cryptococcus species provide key insights into the evolution of sexual reproduction.

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Published In

Annu Rev Genet

DOI

EISSN

1545-2948

Publication Date

December 3, 2019

Volume

53

Start / End Page

417 / 444

Location

United States

Related Subject Headings

  • Spores, Fungal
  • Reproduction
  • Humans
  • Host-Pathogen Interactions
  • Genetics, Population
  • Genes, Mating Type, Fungal
  • Fungal Proteins
  • Developmental Biology
  • Cryptococcus
  • Biological Evolution
 

Citation

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Sun, S., Coelho, M. A., David-Palma, M., Priest, S. J., & Heitman, J. (2019). The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis of Cryptococcus Human Pathogenic Fungi. Annu Rev Genet, 53, 417–444. https://doi.org/10.1146/annurev-genet-120116-024755
Sun, Sheng, Marco A. Coelho, Márcia David-Palma, Shelby J. Priest, and Joseph Heitman. “The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis of Cryptococcus Human Pathogenic Fungi.Annu Rev Genet 53 (December 3, 2019): 417–44. https://doi.org/10.1146/annurev-genet-120116-024755.
Sun S, Coelho MA, David-Palma M, Priest SJ, Heitman J. The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis of Cryptococcus Human Pathogenic Fungi. Annu Rev Genet. 2019 Dec 3;53:417–44.
Sun, Sheng, et al. “The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis of Cryptococcus Human Pathogenic Fungi.Annu Rev Genet, vol. 53, Dec. 2019, pp. 417–44. Pubmed, doi:10.1146/annurev-genet-120116-024755.
Sun S, Coelho MA, David-Palma M, Priest SJ, Heitman J. The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis of Cryptococcus Human Pathogenic Fungi. Annu Rev Genet. 2019 Dec 3;53:417–444.

Published In

Annu Rev Genet

DOI

EISSN

1545-2948

Publication Date

December 3, 2019

Volume

53

Start / End Page

417 / 444

Location

United States

Related Subject Headings

  • Spores, Fungal
  • Reproduction
  • Humans
  • Host-Pathogen Interactions
  • Genetics, Population
  • Genes, Mating Type, Fungal
  • Fungal Proteins
  • Developmental Biology
  • Cryptococcus
  • Biological Evolution