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Prevalence of Cardiovascular Disease Risk Factors in Childhood Glomerular Diseases.

Publication ,  Journal Article
Ashoor, IF; Mansfield, SA; O'Shaughnessy, MM; Parekh, RS; Zee, J; Vasylyeva, TL; Kogon, AJ; Sethna, CB; Glenn, DA; Chishti, AS; Weaver, DJ ...
Published in: J Am Heart Assoc
July 16, 2019

Background Cardiovascular disease is a major cause of morbidity and mortality in children with chronic kidney disease. We sought to determine the prevalence of cardiovascular risk factors in children with glomerular disease and to describe current practice patterns regarding risk factor identification and management. Methods and Results Seven-hundred sixty-one children aged 0 to 17 years with any of 4 biopsy-confirmed primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy/vasculitis) were enrolled at a median of 16 months from glomerular disease diagnosis in the multicenter prospective Cure Glomerulonephropathy Network study. Prevalence of traditional (hypertension, hypercholesterolemia, and obesity) and novel (proteinuria, prematurity, and passive smoke exposure) cardiovascular risk factors were determined at enrollment and compared across glomerular disease subtypes. Frequency of screening for dyslipidemia and prescribing of lipid-lowering or antihypertensive medications were compared across glomerular disease subtype, steroid exposure, and remission status groups. Compared with the general population, all traditional risk factors were more frequent: among those screened, 21% had hypertension, 51% were overweight or obese, and 71% had dyslipidemia. Children who were not in remission at enrollment were more likely to have hypertension and hypercholesterolemia. Fourteen percent of hypertensive children were not receiving antihypertensives. Only 49% underwent screening for dyslipidemia and only 9% of those with confirmed dyslipidemia received lipid-lowering medications. Conclusions Children with primary glomerular diseases exhibit a high frequency of modifiable cardiovascular risk factors, particularly untreated dyslipidemia. Lipid panels should be routinely measured to better define the burden of dyslipidemia in this population. Current approaches to screening for and treating cardiovascular risk factors are not uniform, highlighting a need for evidence-based, disease-specific guidelines.

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Published In

J Am Heart Assoc

DOI

EISSN

2047-9980

Publication Date

July 16, 2019

Volume

8

Issue

14

Start / End Page

e012143

Location

England

Related Subject Headings

  • Tobacco Smoke Pollution
  • Smoking
  • Risk Factors
  • Proteinuria
  • Prevalence
  • Pediatric Obesity
  • Nephrosis, Lipoid
  • Male
  • Infant, Premature
  • Hypolipidemic Agents
 

Citation

APA
Chicago
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Ashoor, I. F., Mansfield, S. A., O’Shaughnessy, M. M., Parekh, R. S., Zee, J., Vasylyeva, T. L., … CureGN Consortium, . (2019). Prevalence of Cardiovascular Disease Risk Factors in Childhood Glomerular Diseases. J Am Heart Assoc, 8(14), e012143. https://doi.org/10.1161/JAHA.119.012143
Ashoor, Isa F., Sarah A. Mansfield, Michelle M. O’Shaughnessy, Rulan S. Parekh, Jarcy Zee, Tetyana L. Vasylyeva, Amy J. Kogon, et al. “Prevalence of Cardiovascular Disease Risk Factors in Childhood Glomerular Diseases.J Am Heart Assoc 8, no. 14 (July 16, 2019): e012143. https://doi.org/10.1161/JAHA.119.012143.
Ashoor IF, Mansfield SA, O’Shaughnessy MM, Parekh RS, Zee J, Vasylyeva TL, et al. Prevalence of Cardiovascular Disease Risk Factors in Childhood Glomerular Diseases. J Am Heart Assoc. 2019 Jul 16;8(14):e012143.
Ashoor, Isa F., et al. “Prevalence of Cardiovascular Disease Risk Factors in Childhood Glomerular Diseases.J Am Heart Assoc, vol. 8, no. 14, July 2019, p. e012143. Pubmed, doi:10.1161/JAHA.119.012143.
Ashoor IF, Mansfield SA, O’Shaughnessy MM, Parekh RS, Zee J, Vasylyeva TL, Kogon AJ, Sethna CB, Glenn DA, Chishti AS, Weaver DJ, Helmuth ME, Fernandez HE, Rheault MN, CureGN Consortium. Prevalence of Cardiovascular Disease Risk Factors in Childhood Glomerular Diseases. J Am Heart Assoc. 2019 Jul 16;8(14):e012143.
Journal cover image

Published In

J Am Heart Assoc

DOI

EISSN

2047-9980

Publication Date

July 16, 2019

Volume

8

Issue

14

Start / End Page

e012143

Location

England

Related Subject Headings

  • Tobacco Smoke Pollution
  • Smoking
  • Risk Factors
  • Proteinuria
  • Prevalence
  • Pediatric Obesity
  • Nephrosis, Lipoid
  • Male
  • Infant, Premature
  • Hypolipidemic Agents