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Depression: The Science of Mental Health

MRI-defined vascular depression

Publication ,  Chapter
Krishnan, KRR; Hays, JC; Blazer, DG
October 15, 2013

OBJECTIVE: The authors' goal was to characterize the clinical and demographic features of vascular depression. METHOD: They classified 89 depressed patients into two groups-those with vascular (N = 32) and nonvascular (N = 57) depression-on the basis of examination of brain magnetic resonance images. All of the patients were enrolled in the National Institute of Mental Health Clinical Research Center for the Study of Depression in Later Life, located at Duke University. The patients with vascular and nonvascular depression were compared on several clinical and demographic risk factors. RESULTS: Bivariate analyses and a fully adjusted logistic regression model revealed that older age, late age at onset, and nonpsychotic subtype occurred more often in patients with vascular depression than in those with nonvascular depression. A family history of mental illness was found somewhat less often, and anhedonia and functional disability were seen somewhat more often in patients with vascular depression. CONCLUSIONS: The profile of patients with vascular depression needs to be developed further. This is likely to have important therapeutic and theoretical implications for the management of these patients.

Duke Scholars

Publication Date

October 15, 2013

Volume

6

Start / End Page

115 / 119
 

Citation

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Krishnan, K. R. R., Hays, J. C., & Blazer, D. G. (2013). MRI-defined vascular depression. In Depression: The Science of Mental Health (Vol. 6, pp. 115–119).
Krishnan, K. R. R., J. C. Hays, and D. G. Blazer. “MRI-defined vascular depression.” In Depression: The Science of Mental Health, 6:115–19, 2013.
Krishnan KRR, Hays JC, Blazer DG. MRI-defined vascular depression. In: Depression: The Science of Mental Health. 2013. p. 115–9.
Krishnan, K. R. R., et al. “MRI-defined vascular depression.” Depression: The Science of Mental Health, vol. 6, 2013, pp. 115–19.
Krishnan KRR, Hays JC, Blazer DG. MRI-defined vascular depression. Depression: The Science of Mental Health. 2013. p. 115–119.

Publication Date

October 15, 2013

Volume

6

Start / End Page

115 / 119