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Estimation of Acutely Ill Medical Patients at Venous Thromboembolism Risk Eligible for Extended Thromboprophylaxis Using APEX Criteria in US Hospitals.

Publication ,  Journal Article
Martin, A-C; Huang, W; Goldhaber, SZ; Hull, RD; Hernandez, AF; Gibson, C-M; Anderson, FA; Cohen, AT
Published in: Clin Appl Thromb Hemost
2019

Major medical illnesses place patients at risk of venous thromboembolism (VTE). Some risk factors including age ≥75 years or history of cancer place them at increased risk of VTE that extends for at least 5 to 6 weeks following hospital admission. Betrixaban thromboprophylaxis is now approved in the United States for this indication. We estimated the annual number of acutely ill medical patients at extended risk of VTE discharged from US hospital. Major medical illnesses (stroke, respiratory failure/chronic obstructive pulmonary disease, heart failure, pneumonia, other infections, and rheumatologic disorders) and 2 common risk factors for extended VTE risk, namely, age ≥75 years and history of cancer (active or past) were examined in 2014 US hospital discharges using the first 3 discharge diagnosis codes in the National Inpatient Sample (database of acute-care hospital discharges from the US Agency for Health Care Quality and Research). In 2014, there were 20.8 million discharges with potentially at risk of nonsurgical-related VTE. Overall, 7.2 million (35%) discharges corresponded to major medical illness that warranted thromboprophylaxis according to 2012 American College of Chest Physicians (ACCP) guideline. Among them, 2.79 million were aged ≥75 years and 1.36 million had a history of cancer (aged 40-74 years). Overall, 3.48 million discharges were at extended risk of VTE. Many medical inpatients at risk of VTE according to 2012 ACCP guideline might benefit from the awareness of continuing risk and some of these patients might benefit from extended thromboprophylaxis, depending on the risk of bleeding and comorbidities.

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Published In

Clin Appl Thromb Hemost

DOI

EISSN

1938-2723

Publication Date

2019

Volume

25

Start / End Page

1076029619880008

Location

United States

Related Subject Headings

  • Venous Thromboembolism
  • United States
  • Risk Assessment
  • Premedication
  • Patient Discharge
  • Middle Aged
  • Male
  • Humans
  • Hospitalization
  • Hemorrhage
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Martin, A.-C., Huang, W., Goldhaber, S. Z., Hull, R. D., Hernandez, A. F., Gibson, C.-M., … Cohen, A. T. (2019). Estimation of Acutely Ill Medical Patients at Venous Thromboembolism Risk Eligible for Extended Thromboprophylaxis Using APEX Criteria in US Hospitals. Clin Appl Thromb Hemost, 25, 1076029619880008. https://doi.org/10.1177/1076029619880008
Martin, Anne-Céline, Wei Huang, Samuel Z. Goldhaber, Russell D. Hull, Adrian F. Hernandez, Charles-Michael Gibson, Frederick A. Anderson, and Alexander T. Cohen. “Estimation of Acutely Ill Medical Patients at Venous Thromboembolism Risk Eligible for Extended Thromboprophylaxis Using APEX Criteria in US Hospitals.Clin Appl Thromb Hemost 25 (2019): 1076029619880008. https://doi.org/10.1177/1076029619880008.
Martin A-C, Huang W, Goldhaber SZ, Hull RD, Hernandez AF, Gibson C-M, et al. Estimation of Acutely Ill Medical Patients at Venous Thromboembolism Risk Eligible for Extended Thromboprophylaxis Using APEX Criteria in US Hospitals. Clin Appl Thromb Hemost. 2019;25:1076029619880008.
Martin, Anne-Céline, et al. “Estimation of Acutely Ill Medical Patients at Venous Thromboembolism Risk Eligible for Extended Thromboprophylaxis Using APEX Criteria in US Hospitals.Clin Appl Thromb Hemost, vol. 25, 2019, p. 1076029619880008. Pubmed, doi:10.1177/1076029619880008.
Martin A-C, Huang W, Goldhaber SZ, Hull RD, Hernandez AF, Gibson C-M, Anderson FA, Cohen AT. Estimation of Acutely Ill Medical Patients at Venous Thromboembolism Risk Eligible for Extended Thromboprophylaxis Using APEX Criteria in US Hospitals. Clin Appl Thromb Hemost. 2019;25:1076029619880008.
Journal cover image

Published In

Clin Appl Thromb Hemost

DOI

EISSN

1938-2723

Publication Date

2019

Volume

25

Start / End Page

1076029619880008

Location

United States

Related Subject Headings

  • Venous Thromboembolism
  • United States
  • Risk Assessment
  • Premedication
  • Patient Discharge
  • Middle Aged
  • Male
  • Humans
  • Hospitalization
  • Hemorrhage