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Surface-enhanced spatially offset Raman spectroscopy (SESORS) for subsurface detection of nanostar probes

Publication ,  Conference
Odion, RA; Strobbia, P; Crawford, BM; Vo-Dinh, T
Published in: Proceedings of SPIE - The International Society for Optical Engineering
January 1, 2019

Early detection of molecular targets can greatly impact the clinical diagnosis and outcome of many diseases such as cancer. Methods utilizing optical detection systems and Surface-Enhanced Raman Scattering (SERS)-labeled nanoparticles provide a way of selectively targeting and obtaining signals unique to the target diseases as well as in-vivo applications for biomass and biofuel research with plants. However, these modalities are often limited to surface level detection due to attenuation from layers of highly scattering and absorbing tissue. In this work, we utilize surface-enhanced spatially offset Raman spectroscopy (SESORS) to probe through thick tissue to overcome this limitation. This modality combines high SERS signals generated by nanoparticles with a depth resolved detection technique called spatially offset Raman spectroscopy (SORS). We show the detection and recovery of SERS signal in layered systems comprising of optically mimicking gel as well as bone material.

Duke Scholars

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

EISSN

1996-756X

ISSN

0277-786X

Publication Date

January 1, 2019

Volume

11007

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

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Odion, R. A., Strobbia, P., Crawford, B. M., & Vo-Dinh, T. (2019). Surface-enhanced spatially offset Raman spectroscopy (SESORS) for subsurface detection of nanostar probes. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 11007). https://doi.org/10.1117/12.2524847
Odion, R. A., P. Strobbia, B. M. Crawford, and T. Vo-Dinh. “Surface-enhanced spatially offset Raman spectroscopy (SESORS) for subsurface detection of nanostar probes.” In Proceedings of SPIE - The International Society for Optical Engineering, Vol. 11007, 2019. https://doi.org/10.1117/12.2524847.
Odion RA, Strobbia P, Crawford BM, Vo-Dinh T. Surface-enhanced spatially offset Raman spectroscopy (SESORS) for subsurface detection of nanostar probes. In: Proceedings of SPIE - The International Society for Optical Engineering. 2019.
Odion, R. A., et al. “Surface-enhanced spatially offset Raman spectroscopy (SESORS) for subsurface detection of nanostar probes.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 11007, 2019. Scopus, doi:10.1117/12.2524847.
Odion RA, Strobbia P, Crawford BM, Vo-Dinh T. Surface-enhanced spatially offset Raman spectroscopy (SESORS) for subsurface detection of nanostar probes. Proceedings of SPIE - The International Society for Optical Engineering. 2019.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

EISSN

1996-756X

ISSN

0277-786X

Publication Date

January 1, 2019

Volume

11007

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering