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Macular Vascular Microcirculation in Eyes With Open-angle Glaucoma Using Different Visual Field Severity Classification Systems.

Publication ,  Journal Article
Bojikian, KD; Nobrega, P; Wen, JC; Zhang, Q; Mudumbai, RC; Johnstone, MA; Wang, RK; Chen, PP
Published in: Journal of glaucoma
September 2019

We found significant differences in macular vascular microcirculation between normal and glaucomatous eyes using optical coherence tomography angiography (OCTA). Macular vascular microcirculation changes also showed significant correlations with visual field (VF) severity classification systems.To correlate VF severity defined by different classification systems and macular vascular microcirculation in eyes with glaucoma using OCTA.Twenty normal and 58 open-angle glaucoma (OAG) eyes were scanned using a swept-source OCTA (Plex Elite 9000) and macular vascular microcirculation was measured by calculating the overall blood flux index (BFI) and vessel area density (VAD) over the entire 6×6 mm area excluding the big retinal vessels. Glaucomatous eyes were staged into severity groups based on 4 VF severity classifications: Hodapp-Parrish-Anderson scale, Glaucoma Severity Staging system, ICD-10 glaucoma staging definitions, and VF mean deviation. Central 10-degree VF mean sensitivity (CMS) was calculated based on 24-2 VF. One-way analysis of variance was used to analyze the differences and correlation between macular vascular microcirculation and other clinical parameters.Glaucomatous eyes had significantly lower ganglion cell and inner plexiform layer BFI and VAD (P<0.0001) compared with normal eyes. In OAG patients, BFI and VAD were significantly higher in mild OAG compared with severe OAG with all VF disease severity classification systems (P<0.001). Glaucoma Severity Staging had the highest correlation with changes in macular vascular microcirculation metrics (r=0.734 for BFI; r=0.647 for VAD) and VF CMS had highest correlation with macular vascular microcirculation metrics (r=0.887 for BFI; r=0.903 for VAD).Macular vascular microcirculation metrics detected by OCTA correlate with disease severity in glaucomatous eyes. VF CMS, calculated from only 12 tested central 10-degree points, correlated best with macular OCTA.

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Published In

Journal of glaucoma

DOI

EISSN

1536-481X

ISSN

1057-0829

Publication Date

September 2019

Volume

28

Issue

9

Start / End Page

790 / 796

Related Subject Headings

  • Visual Fields
  • Vision Disorders
  • Tomography, Optical Coherence
  • Retinal Vessels
  • Retinal Ganglion Cells
  • Optic Disk
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Middle Aged
  • Microcirculation
 

Citation

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Bojikian, K. D., Nobrega, P., Wen, J. C., Zhang, Q., Mudumbai, R. C., Johnstone, M. A., … Chen, P. P. (2019). Macular Vascular Microcirculation in Eyes With Open-angle Glaucoma Using Different Visual Field Severity Classification Systems. Journal of Glaucoma, 28(9), 790–796. https://doi.org/10.1097/ijg.0000000000001308

Published In

Journal of glaucoma

DOI

EISSN

1536-481X

ISSN

1057-0829

Publication Date

September 2019

Volume

28

Issue

9

Start / End Page

790 / 796

Related Subject Headings

  • Visual Fields
  • Vision Disorders
  • Tomography, Optical Coherence
  • Retinal Vessels
  • Retinal Ganglion Cells
  • Optic Disk
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Middle Aged
  • Microcirculation