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The changing landscape of Plasmodium falciparum drug resistance in the Democratic Republic of Congo.

Publication ,  Journal Article
Deutsch-Feldman, M; Aydemir, O; Carrel, M; Brazeau, NF; Bhatt, S; Bailey, JA; Kashamuka, M; Tshefu, AK; Taylor, SM; Juliano, JJ; Meshnick, SR ...
Published in: BMC Infect Dis
October 22, 2019

BACKGROUND: Drug resistant malaria is a growing concern in the Democratic Republic of the Congo (DRC), where previous studies indicate that parasites resistant to sulfadoxine/pyrimethamine or chloroquine are spatially clustered. This study explores longitudinal changes in spatial patterns to understand how resistant malaria may be spreading within the DRC, using samples from nation-wide population-representative surveys. METHODS: We selected 552 children with PCR-detectable Plasmodium falciparum infection and identified known variants in the pfdhps and pfcrt genes associated with resistance. We compared the proportion of mutant parasites in 2013 to those previously reported from adults in 2007, and identified risk factors for carrying a resistant allele using multivariate mixed-effects modeling. Finally, we fit a spatial-temporal model to the observed data, providing smooth allele frequency estimates over space and time. RESULTS: The proportion of co-occurring pfdhps K540E/A581G mutations increased by 16% between 2007 and 2013. The spatial-temporal model suggests that the spatial range of the pfdhps double mutants expanded over time, while the prevalence and range of pfcrt mutations remained steady. CONCLUSIONS: This study uses population-representative samples to describe the changing landscape of SP resistance within the DRC, and the persistence of chloroquine resistance. Vigilant molecular surveillance is critical for controlling the spread of resistance.

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Published In

BMC Infect Dis

DOI

EISSN

1471-2334

Publication Date

October 22, 2019

Volume

19

Issue

1

Start / End Page

872

Location

England

Related Subject Headings

  • Young Adult
  • Sulfadoxine
  • Spatio-Temporal Analysis
  • Pyrimethamine
  • Protozoan Proteins
  • Prevalence
  • Plasmodium falciparum
  • Mutation
  • Middle Aged
  • Microbiology
 

Citation

APA
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MLA
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Deutsch-Feldman, M., Aydemir, O., Carrel, M., Brazeau, N. F., Bhatt, S., Bailey, J. A., … Verity, R. (2019). The changing landscape of Plasmodium falciparum drug resistance in the Democratic Republic of Congo. BMC Infect Dis, 19(1), 872. https://doi.org/10.1186/s12879-019-4523-0
Deutsch-Feldman, Molly, Ozkan Aydemir, Margaret Carrel, Nicholas F. Brazeau, Samir Bhatt, Jeffrey A. Bailey, Melchior Kashamuka, et al. “The changing landscape of Plasmodium falciparum drug resistance in the Democratic Republic of Congo.BMC Infect Dis 19, no. 1 (October 22, 2019): 872. https://doi.org/10.1186/s12879-019-4523-0.
Deutsch-Feldman M, Aydemir O, Carrel M, Brazeau NF, Bhatt S, Bailey JA, et al. The changing landscape of Plasmodium falciparum drug resistance in the Democratic Republic of Congo. BMC Infect Dis. 2019 Oct 22;19(1):872.
Deutsch-Feldman, Molly, et al. “The changing landscape of Plasmodium falciparum drug resistance in the Democratic Republic of Congo.BMC Infect Dis, vol. 19, no. 1, Oct. 2019, p. 872. Pubmed, doi:10.1186/s12879-019-4523-0.
Deutsch-Feldman M, Aydemir O, Carrel M, Brazeau NF, Bhatt S, Bailey JA, Kashamuka M, Tshefu AK, Taylor SM, Juliano JJ, Meshnick SR, Verity R. The changing landscape of Plasmodium falciparum drug resistance in the Democratic Republic of Congo. BMC Infect Dis. 2019 Oct 22;19(1):872.
Journal cover image

Published In

BMC Infect Dis

DOI

EISSN

1471-2334

Publication Date

October 22, 2019

Volume

19

Issue

1

Start / End Page

872

Location

England

Related Subject Headings

  • Young Adult
  • Sulfadoxine
  • Spatio-Temporal Analysis
  • Pyrimethamine
  • Protozoan Proteins
  • Prevalence
  • Plasmodium falciparum
  • Mutation
  • Middle Aged
  • Microbiology