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Association of chemokine expression in anterior cruciate ligament deficient knee with patient characteristics: Implications for post-traumatic osteoarthritis.

Publication ,  Journal Article
Ding, L; Amendola, A; Wolf, B; Bollier, M; Albright, J; Wang, Q; Wu, M; Wang, X; Song, H; Pedersen, D; Martin, J
Published in: Knee
January 2020

BACKGROUND: Stromal cell-derived factor-1a (SDF-1α) and high mobility group box chromosomal protein 1 (HMGB1) are chemokines that can drive post-traumatic osteoarthritis (PTOA) induced by anterior cruciate ligament (ACL) injury. However, the influence of patient characteristics on expression of those chemokines remains unclear. Our aim was to determine the relationship between chemokine expression in synovial fluid (SF) of the ACL-deficient (ACL-D) knee and patient characteristics including time from injury, sex, and age. METHODS: SF samples were collected immediately prior to the first-time ACL reconstruction (ACLR) from 82 patients. Expression of SDF-1α and HMGB1 was measured with human-specific solid phase sandwich enzyme-linked immunosorbent assays. The expression levels between groups divided by time from injury, or age, or sex was compared using Student's t-test. The association of SDF-1α or HMGB1 levels with those variables was determined using regression analysis and Pearson product-moment correlation coefficient. RESULTS: Regression and correlation analysis indicated significant correlation between SDF-1α expression and time from injury in the cohort (r = -0.266, P = 0.016, n = 82) and in females (r = -0.386, P = 0.024, n = 34). Significant correlation was also observed between SDF-1α expression and age in the cohort (r = -0.224, P = 0.043, n = 82) and in males (r = -0.289, P = 0.046, n = 48). No significant correlation between HMGB1 expression and patient characteristics was detected. CONCLUSIONS: SDF-1α rather than HMGB1 might serve as a protein marker for monitoring the development of PTOA in the ACL-D knee, especially in female patients.

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Published In

Knee

DOI

EISSN

1873-5800

Publication Date

January 2020

Volume

27

Issue

1

Start / End Page

36 / 44

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Synovial Fluid
  • Sex Factors
  • Risk Factors
  • Osteoarthritis, Knee
  • Orthopedics
  • Male
  • Humans
  • HMGB1 Protein
  • Female
 

Citation

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Ding, L., Amendola, A., Wolf, B., Bollier, M., Albright, J., Wang, Q., … Martin, J. (2020). Association of chemokine expression in anterior cruciate ligament deficient knee with patient characteristics: Implications for post-traumatic osteoarthritis. Knee, 27(1), 36–44. https://doi.org/10.1016/j.knee.2019.10.014
Ding, Lei, Annunziato Amendola, Brian Wolf, Matthew Bollier, John Albright, Quanming Wang, Minchen Wu, et al. “Association of chemokine expression in anterior cruciate ligament deficient knee with patient characteristics: Implications for post-traumatic osteoarthritis.Knee 27, no. 1 (January 2020): 36–44. https://doi.org/10.1016/j.knee.2019.10.014.
Ding, Lei, et al. “Association of chemokine expression in anterior cruciate ligament deficient knee with patient characteristics: Implications for post-traumatic osteoarthritis.Knee, vol. 27, no. 1, Jan. 2020, pp. 36–44. Pubmed, doi:10.1016/j.knee.2019.10.014.
Ding L, Amendola A, Wolf B, Bollier M, Albright J, Wang Q, Wu M, Wang X, Song H, Pedersen D, Martin J. Association of chemokine expression in anterior cruciate ligament deficient knee with patient characteristics: Implications for post-traumatic osteoarthritis. Knee. 2020 Jan;27(1):36–44.
Journal cover image

Published In

Knee

DOI

EISSN

1873-5800

Publication Date

January 2020

Volume

27

Issue

1

Start / End Page

36 / 44

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Synovial Fluid
  • Sex Factors
  • Risk Factors
  • Osteoarthritis, Knee
  • Orthopedics
  • Male
  • Humans
  • HMGB1 Protein
  • Female