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Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors

Publication ,  Conference
Crawford, BM; Wang, HN; Bowie, ML; Seewaldt, VL; Vo-Dinh, T
Published in: Proceedings of SPIE - The International Society for Optical Engineering
January 1, 2019

Development of simple techniques for detection of nucleic acids is essential for clinical diagnostics. MicroRNA (miRNA) have been identified as potential biomarkers in early detection of various diseases, including esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE). However, these small molecules have not been adopted into clinical practice because of challenging aspects in the lab. The technology described herein is a label-free nanoprobe referred to as "inverse molecular sentinel" (iMS) for gastrointestinal cancer diagnosis using surface-enhanced Raman scattering (SERS) detection. The results of this study provide evidence supporting the robust iMS method for miRNA sensing without the need for PCR.

Duke Scholars

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

EISSN

1996-756X

ISSN

0277-786X

Publication Date

January 1, 2019

Volume

11087

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Crawford, B. M., Wang, H. N., Bowie, M. L., Seewaldt, V. L., & Vo-Dinh, T. (2019). Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 11087). https://doi.org/10.1117/12.2529832
Crawford, B. M., H. N. Wang, M. L. Bowie, V. L. Seewaldt, and T. Vo-Dinh. “Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors.” In Proceedings of SPIE - The International Society for Optical Engineering, Vol. 11087, 2019. https://doi.org/10.1117/12.2529832.
Crawford BM, Wang HN, Bowie ML, Seewaldt VL, Vo-Dinh T. Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors. In: Proceedings of SPIE - The International Society for Optical Engineering. 2019.
Crawford, B. M., et al. “Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 11087, 2019. Scopus, doi:10.1117/12.2529832.
Crawford BM, Wang HN, Bowie ML, Seewaldt VL, Vo-Dinh T. Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors. Proceedings of SPIE - The International Society for Optical Engineering. 2019.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

EISSN

1996-756X

ISSN

0277-786X

Publication Date

January 1, 2019

Volume

11087

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering