Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors
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, Conference
Crawford, BM; Wang, HN; Bowie, ML; Seewaldt, VL; Vo-Dinh, T
Published in: Proceedings of SPIE - The International Society for Optical Engineering
January 1, 2019
Development of simple techniques for detection of nucleic acids is essential for clinical diagnostics. MicroRNA (miRNA) have been identified as potential biomarkers in early detection of various diseases, including esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE). However, these small molecules have not been adopted into clinical practice because of challenging aspects in the lab. The technology described herein is a label-free nanoprobe referred to as "inverse molecular sentinel" (iMS) for gastrointestinal cancer diagnosis using surface-enhanced Raman scattering (SERS) detection. The results of this study provide evidence supporting the robust iMS method for miRNA sensing without the need for PCR.
Duke Scholars
Published In
Proceedings of SPIE - The International Society for Optical Engineering
DOI
EISSN
1996-756X
ISSN
0277-786X
Publication Date
January 1, 2019
Volume
11087
Related Subject Headings
- 5102 Atomic, molecular and optical physics
- 4009 Electronics, sensors and digital hardware
- 4006 Communications engineering
Citation
APA
Chicago
ICMJE
MLA
NLM
Crawford, B. M., Wang, H. N., Bowie, M. L., Seewaldt, V. L., & Vo-Dinh, T. (2019). Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 11087). https://doi.org/10.1117/12.2529832
Crawford, B. M., H. N. Wang, M. L. Bowie, V. L. Seewaldt, and T. Vo-Dinh. “Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors.” In Proceedings of SPIE - The International Society for Optical Engineering, Vol. 11087, 2019. https://doi.org/10.1117/12.2529832.
Crawford BM, Wang HN, Bowie ML, Seewaldt VL, Vo-Dinh T. Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors. In: Proceedings of SPIE - The International Society for Optical Engineering. 2019.
Crawford, B. M., et al. “Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 11087, 2019. Scopus, doi:10.1117/12.2529832.
Crawford BM, Wang HN, Bowie ML, Seewaldt VL, Vo-Dinh T. Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors. Proceedings of SPIE - The International Society for Optical Engineering. 2019.
Published In
Proceedings of SPIE - The International Society for Optical Engineering
DOI
EISSN
1996-756X
ISSN
0277-786X
Publication Date
January 1, 2019
Volume
11087
Related Subject Headings
- 5102 Atomic, molecular and optical physics
- 4009 Electronics, sensors and digital hardware
- 4006 Communications engineering