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What's new in pediatric melanoma: An update from the APSA cancer committee.

Publication ,  Journal Article
Aldrink, JH; Polites, S; Lautz, TB; Malek, MM; Rhee, D; Bruny, J; Christison-Lagay, ER; Tracy, ET; Abdessalam, S; Ehrlich, PF; Dasgupta, R; Austin, MT
Published in: J Pediatr Surg
September 2020

BACKGROUND/PURPOSE: Melanoma is the most common skin cancer in children and often presents in an atypical fashion when compared to adults. The purpose of this review is to present an update on the epidemiology, surgical and medical management and prevention strategies in pediatric melanoma. METHODS: A comprehensive review of the current literature on the epidemiology, surgical and medical management and prevention of adult and pediatric melanoma was performed by the authors and the results of this review are summarized in the manuscript. RESULTS: Most recently, the incidence of melanoma in children has been declining, possibly owing to increased awareness and sun exposure prevention. The mainstay of therapy is surgical resection, often with sentinel lymph node biopsy. A positive sentinel node has prognostic value; however, completion node dissection is no longer recommended in the absence of clinically or radiographically positive nodes. Those with advanced disease also receive adjuvant systemic therapy using increasingly targeted immunologic therapies. CONCLUSIONS: Sentinel lymph node positive patients no longer require completion lymph node dissection and instead may be followed by ultrasound. However, it is important to note that children have been excluded from most melanoma clinical trials to date, and therefore, recommendations for management are based on existing pediatric retrospective data and extrapolation from adult studies. LEVEL OF EVIDENCE: IV.

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Published In

J Pediatr Surg

DOI

EISSN

1531-5037

Publication Date

September 2020

Volume

55

Issue

9

Start / End Page

1714 / 1721

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Prognosis
  • Practice Guidelines as Topic
  • Pediatrics
  • Melanoma
  • Humans
  • Child
  • 3213 Paediatrics
  • 3202 Clinical sciences
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Aldrink, J. H., Polites, S., Lautz, T. B., Malek, M. M., Rhee, D., Bruny, J., … Austin, M. T. (2020). What's new in pediatric melanoma: An update from the APSA cancer committee. J Pediatr Surg, 55(9), 1714–1721. https://doi.org/10.1016/j.jpedsurg.2019.09.036
Aldrink, Jennifer H., Stephanie Polites, Timothy B. Lautz, Marcus M. Malek, Daniel Rhee, Jennifer Bruny, Emily R. Christison-Lagay, et al. “What's new in pediatric melanoma: An update from the APSA cancer committee.J Pediatr Surg 55, no. 9 (September 2020): 1714–21. https://doi.org/10.1016/j.jpedsurg.2019.09.036.
Aldrink JH, Polites S, Lautz TB, Malek MM, Rhee D, Bruny J, et al. What's new in pediatric melanoma: An update from the APSA cancer committee. J Pediatr Surg. 2020 Sep;55(9):1714–21.
Aldrink, Jennifer H., et al. “What's new in pediatric melanoma: An update from the APSA cancer committee.J Pediatr Surg, vol. 55, no. 9, Sept. 2020, pp. 1714–21. Pubmed, doi:10.1016/j.jpedsurg.2019.09.036.
Aldrink JH, Polites S, Lautz TB, Malek MM, Rhee D, Bruny J, Christison-Lagay ER, Tracy ET, Abdessalam S, Ehrlich PF, Dasgupta R, Austin MT. What's new in pediatric melanoma: An update from the APSA cancer committee. J Pediatr Surg. 2020 Sep;55(9):1714–1721.
Journal cover image

Published In

J Pediatr Surg

DOI

EISSN

1531-5037

Publication Date

September 2020

Volume

55

Issue

9

Start / End Page

1714 / 1721

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Prognosis
  • Practice Guidelines as Topic
  • Pediatrics
  • Melanoma
  • Humans
  • Child
  • 3213 Paediatrics
  • 3202 Clinical sciences
  • 1114 Paediatrics and Reproductive Medicine