Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men.
Publication
, Journal Article
Sarkar, M; Yates, K; Suzuki, A; Lavine, J; Gill, R; Ziegler, T; Terrault, N; Dhindsa, S
Published in: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
February 2021
With rising prevalence of obesity and diabetes, nonalcoholic fatty liver disease (NAFLD) is now a leading cause of chronic liver disease. One-third of obese or diabetic men have subnormal free and bioavailable testosterone concentrations.1 Several studies have further shown low testosterone to be associated with imaging-confirmed NAFLD in men,2 although it is unknown whether low testosterone confers increased risk of more clinically relevant manifestations of NAFLD, including nonalcoholic steatohepatitis (NASH) and NASH fibrosis. We therefore aimed to evaluate the association of testosterone with histologic features of NAFLD among a representative cohort of men from the multicenter NASH Clinical Research Network (NASH CRN).
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
DOI
EISSN
1542-7714
ISSN
1542-3565
Publication Date
February 2021
Volume
19
Issue
2
Start / End Page
400 / 402.e2
Related Subject Headings
- Testosterone
- Obesity
- Non-alcoholic Fatty Liver Disease
- Male
- Liver
- Humans
- Gastroenterology & Hepatology
- Fibrosis
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Sarkar, M., Yates, K., Suzuki, A., Lavine, J., Gill, R., Ziegler, T., … Dhindsa, S. (2021). Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men. Clinical Gastroenterology and Hepatology : The Official Clinical Practice Journal of the American Gastroenterological Association, 19(2), 400-402.e2. https://doi.org/10.1016/j.cgh.2019.11.053
Published In
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
DOI
EISSN
1542-7714
ISSN
1542-3565
Publication Date
February 2021
Volume
19
Issue
2
Start / End Page
400 / 402.e2
Related Subject Headings
- Testosterone
- Obesity
- Non-alcoholic Fatty Liver Disease
- Male
- Liver
- Humans
- Gastroenterology & Hepatology
- Fibrosis
- 3202 Clinical sciences
- 1103 Clinical Sciences