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Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men.

Publication ,  Journal Article
Sarkar, M; Yates, K; Suzuki, A; Lavine, J; Gill, R; Ziegler, T; Terrault, N; Dhindsa, S
Published in: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
February 2021

With rising prevalence of obesity and diabetes, nonalcoholic fatty liver disease (NAFLD) is now a leading cause of chronic liver disease. One-third of obese or diabetic men have subnormal free and bioavailable testosterone concentrations.1 Several studies have further shown low testosterone to be associated with imaging-confirmed NAFLD in men,2 although it is unknown whether low testosterone confers increased risk of more clinically relevant manifestations of NAFLD, including nonalcoholic steatohepatitis (NASH) and NASH fibrosis. We therefore aimed to evaluate the association of testosterone with histologic features of NAFLD among a representative cohort of men from the multicenter NASH Clinical Research Network (NASH CRN).

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Published In

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

DOI

EISSN

1542-7714

ISSN

1542-3565

Publication Date

February 2021

Volume

19

Issue

2

Start / End Page

400 / 402.e2

Related Subject Headings

  • Testosterone
  • Obesity
  • Non-alcoholic Fatty Liver Disease
  • Male
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Fibrosis
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Sarkar, M., Yates, K., Suzuki, A., Lavine, J., Gill, R., Ziegler, T., … Dhindsa, S. (2021). Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men. Clinical Gastroenterology and Hepatology : The Official Clinical Practice Journal of the American Gastroenterological Association, 19(2), 400-402.e2. https://doi.org/10.1016/j.cgh.2019.11.053
Journal cover image

Published In

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

DOI

EISSN

1542-7714

ISSN

1542-3565

Publication Date

February 2021

Volume

19

Issue

2

Start / End Page

400 / 402.e2

Related Subject Headings

  • Testosterone
  • Obesity
  • Non-alcoholic Fatty Liver Disease
  • Male
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Fibrosis
  • 3202 Clinical sciences
  • 1103 Clinical Sciences