Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Alternative polyadenylation of mRNA and its role in cancer.

Publication ,  Journal Article
Yuan, F; Hankey, W; Wagner, EJ; Li, W; Wang, Q
Published in: Genes Dis
January 2021

Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3' end of RNA polymerase II transcripts from over 60% of human genes. APA is derived from the existence of multiple polyadenylation signals (PAS) within the same transcript, and results in the differential inclusion of sequence information at the 3' end. While APA can occur between two PASs allowing for generation of transcripts with distinct coding potential from a single gene, most APA occurs within the untranslated region (3'UTR) and changes the length and content of these non-coding sequences. APA within the 3'UTR can have tremendous impact on its regulatory potential of the mRNA through a variety of mechanisms, and indeed this layer of gene expression regulation has profound impact on processes vital to cell growth and development. Recent studies have particularly highlighted the importance of APA dysregulation in cancer onset and progression. Here, we review the current knowledge of APA and its impacts on mRNA stability, translation, localization and protein localization. We also discuss the implications of APA dysregulation in cancer research and therapy.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Genes Dis

DOI

EISSN

2352-3042

Publication Date

January 2021

Volume

8

Issue

1

Start / End Page

61 / 72

Location

Netherlands
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yuan, F., Hankey, W., Wagner, E. J., Li, W., & Wang, Q. (2021). Alternative polyadenylation of mRNA and its role in cancer. Genes Dis, 8(1), 61–72. https://doi.org/10.1016/j.gendis.2019.10.011
Yuan, Fuwen, William Hankey, Eric J. Wagner, Wei Li, and Qianben Wang. “Alternative polyadenylation of mRNA and its role in cancer.Genes Dis 8, no. 1 (January 2021): 61–72. https://doi.org/10.1016/j.gendis.2019.10.011.
Yuan F, Hankey W, Wagner EJ, Li W, Wang Q. Alternative polyadenylation of mRNA and its role in cancer. Genes Dis. 2021 Jan;8(1):61–72.
Yuan, Fuwen, et al. “Alternative polyadenylation of mRNA and its role in cancer.Genes Dis, vol. 8, no. 1, Jan. 2021, pp. 61–72. Pubmed, doi:10.1016/j.gendis.2019.10.011.
Yuan F, Hankey W, Wagner EJ, Li W, Wang Q. Alternative polyadenylation of mRNA and its role in cancer. Genes Dis. 2021 Jan;8(1):61–72.
Journal cover image

Published In

Genes Dis

DOI

EISSN

2352-3042

Publication Date

January 2021

Volume

8

Issue

1

Start / End Page

61 / 72

Location

Netherlands