IN vivo cancer diagnosis of the esophagus using laser-induced fluorescence

Laserinduced fluorescence (LIF) was used for direct in-viva cancer diagnosis of the esophagus without requiring biopsy. The methodology was applied to differentiate normal and malignant tumors of the esophagus. Endogenous fluorescence of normal and malignant tissues were measured directly using a fiberoptic probe inserted through an endoscope. The measurements were pertormed in vivo during routine endoscopy. Detection of the fluorescence signal from the tissue was pertormed using laser excitation. The results of this LIF approach were compared with histopathology results of the biopsy samples and indicated excellent agreement in the classification of normal and malignant tumors for the samples investigated. The LIF procedure could lead to the development of a rapid and cost-effective technique for cancer diagnosis.

Duke Scholars

Author Tuan Vo-Dinh Biomedical Engineering