Test Accuracy of Human Papillomavirus in Urine for Detection of Cervical Intraepithelial Neoplasia.
The objective was to assess the diagnostic test accuracy of high-risk human papillomavirus (hrHPV) testing of self-collected urine and cervicovaginal samples for the detection of cervical intraepithelial neoplasia grade 2 or higher (CIN2+). We recruited a convenience sample of women 25 to 65 years of age who were undergoing clinically indicated colposcopy at two medical centers in North Carolina between November 2016 and January 2019. Women with normal cytology results and positive hrHPV results were also recruited. Urine samples, self-collected cervicovaginal samples, provider-collected cervical samples, and cervical biopsy samples were obtained from all enrolled women. Samples were tested for hrHPV DNA using the Onclarity assay (Becton Dickinson, Sparks, MD). Biopsy samples were histologically graded as CIN2+ or
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Related Subject Headings
- Uterine Cervical Neoplasms
- Uterine Cervical Dysplasia
- Specimen Handling
- Sensitivity and Specificity
- Polymerase Chain Reaction
- Papillomavirus Infections
- Papillomaviridae
- North Carolina
- Middle Aged
- Microbiology
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Location
Related Subject Headings
- Uterine Cervical Neoplasms
- Uterine Cervical Dysplasia
- Specimen Handling
- Sensitivity and Specificity
- Polymerase Chain Reaction
- Papillomavirus Infections
- Papillomaviridae
- North Carolina
- Middle Aged
- Microbiology