Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Loss of centromere function drives karyotype evolution in closely related Malassezia species.

Publication ,  Journal Article
Sankaranarayanan, SR; Ianiri, G; Coelho, MA; Reza, MH; Thimmappa, BC; Ganguly, P; Vadnala, RN; Sun, S; Siddharthan, R; Tellgren-Roth, C ...
Published in: Elife
January 20, 2020

Genomic rearrangements associated with speciation often result in variation in chromosome number among closely related species. Malassezia species show variable karyotypes ranging between six and nine chromosomes. Here, we experimentally identified all eight centromeres in M. sympodialis as 3-5-kb long kinetochore-bound regions that span an AT-rich core and are depleted of the canonical histone H3. Centromeres of similar sequence features were identified as CENP-A-rich regions in Malassezia furfur, which has seven chromosomes, and histone H3 depleted regions in Malassezia slooffiae and Malassezia globosa with nine chromosomes each. Analysis of synteny conservation across centromeres with newly generated chromosome-level genome assemblies suggests two distinct mechanisms of chromosome number reduction from an inferred nine-chromosome ancestral state: (a) chromosome breakage followed by loss of centromere DNA and (b) centromere inactivation accompanied by changes in DNA sequence following chromosome-chromosome fusion. We propose that AT-rich centromeres drive karyotype diversity in the Malassezia species complex through breakage and inactivation.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Elife

DOI

EISSN

2050-084X

Publication Date

January 20, 2020

Volume

9

Location

England

Related Subject Headings

  • Species Specificity
  • Malassezia
  • Karyotyping
  • Evolution, Molecular
  • Chromosomes, Fungal
  • Centromere
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 0601 Biochemistry and Cell Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sankaranarayanan, S. R., Ianiri, G., Coelho, M. A., Reza, M. H., Thimmappa, B. C., Ganguly, P., … Sanyal, K. (2020). Loss of centromere function drives karyotype evolution in closely related Malassezia species. Elife, 9. https://doi.org/10.7554/eLife.53944
Sankaranarayanan, Sundar Ram, Giuseppe Ianiri, Marco A. Coelho, Md Hashim Reza, Bhagya C. Thimmappa, Promit Ganguly, Rakesh Netha Vadnala, et al. “Loss of centromere function drives karyotype evolution in closely related Malassezia species.Elife 9 (January 20, 2020). https://doi.org/10.7554/eLife.53944.
Sankaranarayanan SR, Ianiri G, Coelho MA, Reza MH, Thimmappa BC, Ganguly P, et al. Loss of centromere function drives karyotype evolution in closely related Malassezia species. Elife. 2020 Jan 20;9.
Sankaranarayanan, Sundar Ram, et al. “Loss of centromere function drives karyotype evolution in closely related Malassezia species.Elife, vol. 9, Jan. 2020. Pubmed, doi:10.7554/eLife.53944.
Sankaranarayanan SR, Ianiri G, Coelho MA, Reza MH, Thimmappa BC, Ganguly P, Vadnala RN, Sun S, Siddharthan R, Tellgren-Roth C, Dawson TL, Heitman J, Sanyal K. Loss of centromere function drives karyotype evolution in closely related Malassezia species. Elife. 2020 Jan 20;9.

Published In

Elife

DOI

EISSN

2050-084X

Publication Date

January 20, 2020

Volume

9

Location

England

Related Subject Headings

  • Species Specificity
  • Malassezia
  • Karyotyping
  • Evolution, Molecular
  • Chromosomes, Fungal
  • Centromere
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 0601 Biochemistry and Cell Biology