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Surgical resection of locally advanced granular cell tumor of the orbit.

Publication ,  Journal Article
Golio, DI; Prabhu, S; Hauck, EF; Esmaeli, B
Published in: J Craniofac Surg
May 2006

We report a case of locally advanced granular cell tumor of the orbit treated by a multidisciplinary surgical approach. A 49-year-old woman with a recently biopsied granular cell tumor of the orbit was referred to our tertiary care cancer center for evaluation of a right-sided globe ptosis and a palpable mass in the right orbit that had been present for approximately two years. Magnetic resonance imaging showed a large orbital mass that extended posteriorly to the orbital apex and anteriorly to the levator and superior rectus muscle complex. A workup including computed tomography of the chest, abdomen, and pelvis did not show any metastatic foci. Surgical resection of the mass was undertaken via a frontozygomatic craniotomy supplemented by an anterior orbitotomy to repair the levator aponeurosis and the superior oblique tendon, which were partially resected with the mass. Histologic evaluation of the mass revealed solid nests of polygonal cells that had centrally located, round nuclei with abundant eosinophilic granular cytoplasm. The cytoplasmic granules were positive on the periodic acid-Schiff reaction and were diastase-resistant. Immunohistochemical staining was positive for S-100 protein. During the most recent follow-up visit six months after surgery, the patient had no clinical evidence of tumor recurrence, had minimal residual ptosis and exposure keratopathy, and had stable visual function.

Duke Scholars

Published In

J Craniofac Surg

DOI

ISSN

1049-2275

Publication Date

May 2006

Volume

17

Issue

3

Start / End Page

594 / 598

Location

United States

Related Subject Headings

  • Zygoma
  • Tomography, X-Ray Computed
  • S100 Proteins
  • Orbital Neoplasms
  • Orbit
  • Oculomotor Muscles
  • Middle Aged
  • Humans
  • Granular Cell Tumor
  • Frontal Bone
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Golio, D. I., Prabhu, S., Hauck, E. F., & Esmaeli, B. (2006). Surgical resection of locally advanced granular cell tumor of the orbit. J Craniofac Surg, 17(3), 594–598. https://doi.org/10.1097/00001665-200605000-00037
Golio, Dominick I., Sujit Prabhu, Erik F. Hauck, and Bita Esmaeli. “Surgical resection of locally advanced granular cell tumor of the orbit.J Craniofac Surg 17, no. 3 (May 2006): 594–98. https://doi.org/10.1097/00001665-200605000-00037.
Golio DI, Prabhu S, Hauck EF, Esmaeli B. Surgical resection of locally advanced granular cell tumor of the orbit. J Craniofac Surg. 2006 May;17(3):594–8.
Golio, Dominick I., et al. “Surgical resection of locally advanced granular cell tumor of the orbit.J Craniofac Surg, vol. 17, no. 3, May 2006, pp. 594–98. Pubmed, doi:10.1097/00001665-200605000-00037.
Golio DI, Prabhu S, Hauck EF, Esmaeli B. Surgical resection of locally advanced granular cell tumor of the orbit. J Craniofac Surg. 2006 May;17(3):594–598.

Published In

J Craniofac Surg

DOI

ISSN

1049-2275

Publication Date

May 2006

Volume

17

Issue

3

Start / End Page

594 / 598

Location

United States

Related Subject Headings

  • Zygoma
  • Tomography, X-Ray Computed
  • S100 Proteins
  • Orbital Neoplasms
  • Orbit
  • Oculomotor Muscles
  • Middle Aged
  • Humans
  • Granular Cell Tumor
  • Frontal Bone